RESEARCH Open Access

Experimental acute lung injury induces multi-organ epigenetic modifications in key angiogenic genes implicated in sepsis-associated endothelial cause of sepsis in critically ill patients, elucidation of mechanisms mediating epigenetic alterations during sepsis Bomsztyk et al. Critical Care (2015) 19:225 DOI 10.1186/s13054-015-0943-498195 Seattle, WA, USA Full list of author information is available at the end of the articleprovides fundamental new insights into the pathogenesis of sepsis-induced microvascular leak and subsequent end-organ injury/dysfunction