Obesity and Risk of Sepsis: A Population-Based Cohort Study

OBJECTIVE—Sepsis, the syndrome of microbial infection complicated by systemic inflammation, is associated with significant morbidity and mortality. We sought to determine if obesity increases risk of sepsis events. DESIGN AND METHODS—We used data from the 30,239 subject population-based longitudinal cohort study REasons for Geographic and Racial Differences in Stroke (REGARDS). Using measurements at the start of the study, we defined obesity using body mass index (BMI; <18.5 kg/m2=underweight, 18.5–24.9 =normal, 25.0–29.9=overweight, 30.0–39.9=obese, ≥40=morbidly obese) and waist circumference (WC; [male≤102 cm or female≤88 cm] = normal, [male>102 cm or female>88 cm]=obese). Over an 8-year observation period, we evaluated the association between obesity and subsequent sepsis events, adjusting for sociodemographic factors, health behaviors, chronic medical conditions, statin use and high-sensitivity C-reactive protein. RESULTS—There were 975 incident sepsis events. Compared to those with a BMI of 18.5–24.9, sepsis risk was higher only for BMI ≥40 (HR 1.57, (1.16–2.14)). Risk of sepsis was associated with increased WC (HR 1.34 (1.14–1.56)). In a model with both BMI and WC, sepsis risk wa