Add to ORKGThe activation of nuclear factor kappa B (NF-kB) plays a major role in the pathogenesis of a number of inflammatory diseases. In this study, we investigated the anti-inflammatory mechanism of Gelam honey in inflammation induced rats via NF-kB signalling pathway. Rats paw edema was induced by subplantar injection of 1 % carrageenan into the right hind paw. Rats were pre-treated with Gelam honey at different doses (1 or 2 g/kg, p.o.) and NSAID Indomethacin (10 mg/kg, p.o.), in two time points (1 and 7 days). Our results showed that Gelam honey at both concentrations suppressed the gene expressions of NF-kB (p65 & p50) and IkBa in inflamed rats paw tissues. In addition, Gelam honey inhibited the nuclear translocation and activation of NF-k...
Monocytes and macrophages are part of the first-line defense against bacterial, fungal, and viral in...
<p>Rats pre-treated with: (<b>A</b>) D.W., (<b>B</b>) 2 g/kg Gelam honey, (<b>C</b>) D.W.+Carr., (<b...
Gelam honey exerts anti-inflammatory and antioxidant activities and is thought to have potent effect...
The activation of nuclear factor kappa B (NF-κB) plays a major role in the pathogenesis of a number ...
<p>Activation of NF-κB pathway by different inflammatory stimuli leads to phosphorylation of inhibit...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
<p>(<b>A</b>) Cytosolic NF-κB subunits p65 & p50 and (<b>B</b>) Nuclear NF-κB subunits p65 & p50. Ra...
<p>(<b>A</b>) NF-κB (p65) (<b>B</b>) NF-κB (p50) and (<b>C</b>) IκBα. Rats were pretreated orally wi...
We investigated the effects of honey and its methanol and ethyl acetate extracts on inflammation in ...
<p>Rats were pretreated orally with Gelam honey (1 or 2 g/kg of body weight) for 1 or 7 days before ...
Persistent systemic inflammatory response syndrome is a serious health condition that may lead to m...
<p>Hematoxylin and Eosin staining of paw tissues of rats pre-treated with: (<b>A</b>) D.W., (<b>B</b...
Purpose. Type 2 diabetes consists of progressive hyperglycemia and insulin resistance, which could r...
AbstractAllergic asthma is a chronic inflammatory disorder of the pulmonary airways. Gelam honey has...
This study aimed to evaluate the anti-inflammatory activities of eight different types of Yemeni hon...
Monocytes and macrophages are part of the first-line defense against bacterial, fungal, and viral in...
<p>Rats pre-treated with: (<b>A</b>) D.W., (<b>B</b>) 2 g/kg Gelam honey, (<b>C</b>) D.W.+Carr., (<b...
Gelam honey exerts anti-inflammatory and antioxidant activities and is thought to have potent effect...
The activation of nuclear factor kappa B (NF-κB) plays a major role in the pathogenesis of a number ...
<p>Activation of NF-κB pathway by different inflammatory stimuli leads to phosphorylation of inhibit...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
<p>(<b>A</b>) Cytosolic NF-κB subunits p65 & p50 and (<b>B</b>) Nuclear NF-κB subunits p65 & p50. Ra...
<p>(<b>A</b>) NF-κB (p65) (<b>B</b>) NF-κB (p50) and (<b>C</b>) IκBα. Rats were pretreated orally wi...
We investigated the effects of honey and its methanol and ethyl acetate extracts on inflammation in ...
<p>Rats were pretreated orally with Gelam honey (1 or 2 g/kg of body weight) for 1 or 7 days before ...
Persistent systemic inflammatory response syndrome is a serious health condition that may lead to m...
<p>Hematoxylin and Eosin staining of paw tissues of rats pre-treated with: (<b>A</b>) D.W., (<b>B</b...
Purpose. Type 2 diabetes consists of progressive hyperglycemia and insulin resistance, which could r...
AbstractAllergic asthma is a chronic inflammatory disorder of the pulmonary airways. Gelam honey has...
This study aimed to evaluate the anti-inflammatory activities of eight different types of Yemeni hon...
Monocytes and macrophages are part of the first-line defense against bacterial, fungal, and viral in...
<p>Rats pre-treated with: (<b>A</b>) D.W., (<b>B</b>) 2 g/kg Gelam honey, (<b>C</b>) D.W.+Carr., (<b...
Gelam honey exerts anti-inflammatory and antioxidant activities and is thought to have potent effect...