Add to ORKGIntroduction: Development of secondary hyperalgesia following a cutaneous injury is a centrally mediated, robust phenomenon. The pathophysiological role of endogenous opioid signalling to the development of hyperalgesia is unclear. Recent animal studies, carried out after the resolution of inflammatory pain, have demonstrated reinstatement of tactile hypersensitivity following administration of m-opioid-receptor-antagonists. In the present study in humans, we analyzed the effect of naloxone when given after the resolution of secondary hyperalgesia following a first-degree burn injury
Opioids are the most frequently used drugs to relieve moderate to severe pain. In addition to their ...
Using behavioral, immunohistochemical and pharmacological studies, we report here that large thoraci...
Opioids have been utilized for millennia for analgesia, but are accompanied by numerous adverse effe...
Introduction:Development of secondary hyperalgesia following a cutaneous injury is a centrally media...
Development of secondary hyperalgesia following a cutaneous injury is a centrally mediated, robust p...
INTRODUCTION: Development of secondary hyperalgesia following a cutaneous injury is a centrally medi...
Severe chronic postsurgical pain has a prevalence of 4-10% in the surgical population. The underlyin...
Severe chronic postsurgical pain has a prevalence of 4–10% in the surgical population. The underlyin...
<p>Individual secondary hyperalgesia areas (▵-values = post-infusion area – pre-infusion area) at bu...
The heat pain threshold was assessed in 32 healthy participants after a mild burn on the dorsal surf...
Following the resolution of a severe inflammatory injury in rodents, administration of mu-opioid rec...
<div><p>Following the resolution of a severe inflammatory injury in rodents, administration of mu-op...
<p>Individual trajectories of secondary hyperalgesia areas (n = 12) during the early phase (0–3 hrs)...
Abstract We previously showed that the progression of burn-induced injury was inhibited by exposing ...
We sought to determine whether stimulation of opioid receptors during body cooling would alter sensi...
Opioids are the most frequently used drugs to relieve moderate to severe pain. In addition to their ...
Using behavioral, immunohistochemical and pharmacological studies, we report here that large thoraci...
Opioids have been utilized for millennia for analgesia, but are accompanied by numerous adverse effe...
Introduction:Development of secondary hyperalgesia following a cutaneous injury is a centrally media...
Development of secondary hyperalgesia following a cutaneous injury is a centrally mediated, robust p...
INTRODUCTION: Development of secondary hyperalgesia following a cutaneous injury is a centrally medi...
Severe chronic postsurgical pain has a prevalence of 4-10% in the surgical population. The underlyin...
Severe chronic postsurgical pain has a prevalence of 4–10% in the surgical population. The underlyin...
<p>Individual secondary hyperalgesia areas (▵-values = post-infusion area – pre-infusion area) at bu...
The heat pain threshold was assessed in 32 healthy participants after a mild burn on the dorsal surf...
Following the resolution of a severe inflammatory injury in rodents, administration of mu-opioid rec...
<div><p>Following the resolution of a severe inflammatory injury in rodents, administration of mu-op...
<p>Individual trajectories of secondary hyperalgesia areas (n = 12) during the early phase (0–3 hrs)...
Abstract We previously showed that the progression of burn-induced injury was inhibited by exposing ...
We sought to determine whether stimulation of opioid receptors during body cooling would alter sensi...
Opioids are the most frequently used drugs to relieve moderate to severe pain. In addition to their ...
Using behavioral, immunohistochemical and pharmacological studies, we report here that large thoraci...
Opioids have been utilized for millennia for analgesia, but are accompanied by numerous adverse effe...