HigherMagnesium Intake Reduces Risk of Impaired Glucose and Insulin Metabolism and Progression From Prediabetes to Diabetes in Middle-Aged Americans OBJECTIVE

To assess 7-year associations between magnesium intake and incident predia-betes and/or insulin resistance (IR), and progression from these states to type 2 diabetes. RESEARCH DESIGN AND METHODS In 2,582 community-dwelling participants 26–81 years old at baseline, magnesium intake and risk of incident “metabolic impairment, ” defined as impaired fasting glucose (FG) (‡5.6 to,7.0 mmol/L), impaired glucose tolerance (2-h postload glucose ‡7.8 to,11.1 mmol/L), IR, or hyperinsulinemia (‡90th percentile of ho-meostasis model assessment of IR or fasting insulin, respectively), was estimated among those with normal baseline status, and risk of incident diabetes was es-timated among those with baseline metabolic impairment. In participants with-out incident diabetes, we examined magnesium intake in relation to 7-year changes in fasting and postload glucose and insulin, IR, and insulin sensitivity. RESULTS After adjusting for age, sex, and energy intake, compared with those with th