Research Article Correlation between Peripheral Levels of Brain-Derived Neurotrophic Factor and Hippocampal Volume in Children and Adolescents with Bipolar Disorder

Copyright © 2015 Tatiana Lauxen Peruzzolo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Pediatric bipolar disorder (PBD) is a seriousmental disorder that affects the development and emotional growth of affected patients. The brain derived neurotrophic factor (BDNF) is recognized as one of the possible markers of the framework and its evolution. Abnormalities in BDNF signaling in the hippocampus could explain the cognitive decline seen in patients with TB. Our aim with this study was to evaluate possible changes in hippocampal volume in children and adolescents with BD and associate them to serumBDNF. Subjects included 30 patients aged seven to seventeen years from the ProCAB (Program for Children andAdolescents with Bipolar Disorder). We observed mean right and left hippocampal volumes of 41910.55 and 41747.96mm3, respectively. N