RESEARCH Open Access Dipyridamole augments the antiinflammatory response during human endotoxemia

Introduction: In animal models of systemic inflammation, the endogenous nucleoside adenosine controls inflammation and prevents organ injury. Dipyridamole blocks the cellular uptake of endogenous adenosine and increases the extracellular adenosine concentration. We studied the effects of oral dipyridamole treatment on innate immunity and organ injury during human experimental endotoxemia. Methods: In a randomized double-blind placebo-controlled study, 20 healthy male subjects received 2 ng/k