Add to ORKGRegulatory T cells (Treg) play an important role in fetal protection. They expand during normal pregnancy and protect fetal antigens from maternal effector cells. Their effect is associated with the up-regulation of tolerance-associated molecules at the fetal-maternal interface. Among these, Heme Oxygenase-1 (HO-1, coded by Hmox1) is of special importance as its blockage correlates with increased abortion rates and its up-regulation positively affects pregnancy outcome. Here, we aimed to investigate whether the protective effect of Treg is mediated by HO-1 in a mouse model. HO-1 blockage by Zinc Protoporhyrin (ZnPPIX) abrogated the protective effect of Treg transfer. We found that HO-1 is important in maintaining maternal dendritic cells (D...
Preeclampsia, fetal growth restriction, and miscarriage remain important causes of maternal and peri...
Heme oxygenase (HO) is the rate-limiting enzyme in the heme catabolic pathway and highly expressed i...
Intrauterine growth restriction (IUGR) affects up to 10% of pregnancies in Western societies. IUGR i...
Regulatory T cells (Treg) play an important role in fetal protection. They expand during normal preg...
<div><p>Regulatory T cells (Treg) play an important role in fetal protection. They expand during nor...
Both infectious as non-infectious inflammation can cause placental dysfunction and pregnancy complic...
BACKGROUND: Necrotizing enterocolitis (NEC), an intestinal inflammatory disease affecting premature ...
Die Schwangerschaft ist ein komplexes Phänomen, bei dem es zu einer Interaktion zwischen dem mütterl...
The pregnancy hormone human chorionic gonadotropin (hCG) has been suggested to play an immunoregulat...
Dendritic cells (DCs) are critical for instructing immune responses toward inflammatory or anti-infl...
Having previously demonstrated that heme oxygenase (HO) is expressed on invasive trophoblast within ...
Adaptation of the maternal immune response to accommodate the semi-allogeneic fetus is necessary for...
Adaptation of the maternal immune response to accommodate the semi-allogeneic fetus is necessary for...
A fetus is inherently antigenic to its mother and yet is not rejected. The T regulatory (Treg) subse...
Implantation of the fertilized egg depends on the coordinated interplay of cells and molecules that ...
Preeclampsia, fetal growth restriction, and miscarriage remain important causes of maternal and peri...
Heme oxygenase (HO) is the rate-limiting enzyme in the heme catabolic pathway and highly expressed i...
Intrauterine growth restriction (IUGR) affects up to 10% of pregnancies in Western societies. IUGR i...
Regulatory T cells (Treg) play an important role in fetal protection. They expand during normal preg...
<div><p>Regulatory T cells (Treg) play an important role in fetal protection. They expand during nor...
Both infectious as non-infectious inflammation can cause placental dysfunction and pregnancy complic...
BACKGROUND: Necrotizing enterocolitis (NEC), an intestinal inflammatory disease affecting premature ...
Die Schwangerschaft ist ein komplexes Phänomen, bei dem es zu einer Interaktion zwischen dem mütterl...
The pregnancy hormone human chorionic gonadotropin (hCG) has been suggested to play an immunoregulat...
Dendritic cells (DCs) are critical for instructing immune responses toward inflammatory or anti-infl...
Having previously demonstrated that heme oxygenase (HO) is expressed on invasive trophoblast within ...
Adaptation of the maternal immune response to accommodate the semi-allogeneic fetus is necessary for...
Adaptation of the maternal immune response to accommodate the semi-allogeneic fetus is necessary for...
A fetus is inherently antigenic to its mother and yet is not rejected. The T regulatory (Treg) subse...
Implantation of the fertilized egg depends on the coordinated interplay of cells and molecules that ...
Preeclampsia, fetal growth restriction, and miscarriage remain important causes of maternal and peri...
Heme oxygenase (HO) is the rate-limiting enzyme in the heme catabolic pathway and highly expressed i...
Intrauterine growth restriction (IUGR) affects up to 10% of pregnancies in Western societies. IUGR i...