Open Access A Case of von Hippel–Lindau Disease with Colorectal

von Hippel–Lindau (VHL) disease is an autosomal dominant inherited tumor syn-drome associated with mutations of the VHL tumor suppressor gene located on chro-mosome 3p25. The loss of functional VHL protein contributes to tumorigenesis. This condition is characterized by development of benign and malignant tumors in the central nervous system (CNS) and the internal organs, including kidney, adrenal gland, and pancreas. We herein describe the case of a 74-year-old man carrying the VHL gene mutation who was affected by simultaneous colorectal adenocarcinoma, renal clear cell carcinoma, and hemangioblastomas of CNS. Key words von Hippel-Lindau disease, Colorectal neoplasm