Protein Tyrosine Kinase 6 (PTK6) is a non-receptor type tyrosine kinase that may be involved in some cancers. However, the biological role and expression status of PTK6 in pancreatic cancer is unknown. Therefore in this study, we evaluated the functional role of PTK6 on pancreatic cancer invasion. Five pancreatic cancer cell lines expressed PTK6 at varying levels. PTK6 expression was also observed in human pancreatic adenocarcinomas. PTK6 suppression by siRNA significantly reduced both cellular migration and invasion (0.59/0.49 fold for BxPC3, 0.61/0.62 for Panc1, 0.42/0.39 for MIAPaCa2, respectively, p,0.05 for each). In contrast, forced overexpression of PTK6 by transfection of a PTK6 expression vector in Panc1 and MIAPaCa2 cells increase...
<div><p>Pancreatic cancer is a very aggressive disease with few therapeutic options. In this study, ...
Pancreatic cancer is a very aggressive disease with few therapeutic options. In this study, we inves...
Pancreatic cancer, one of the deadliest human malignancies, is almost invariably associated with the...
Protein Tyrosine Kinase 6 (PTK6) is a non-receptor type tyrosine kinase that may be involved in some...
<p><b><i>A</i>,</b> Overexpression of PTK6. Cells were transfected with pcDNA3.1-Mock (empty vector)...
<p><b><i>A</i>,</b> PTK6 gene silencing. Cells were transfected with PTK6-specific siRNA (siRNA-PTK6...
<p><b><i>A</i>,</b> Effect of PTK6 gene silencing on total ERK1/2 and activated (phosphorylated) ERK...
PTK6, also known as Brk, is highly expressed in over 80% of breast cancers. In the last decade sever...
The non-receptor tyrosine kinase, PTK6/BRK, is highly expressed in multiple tumor types, including p...
PTK6 (also known as Brk) is an intracellular tyrosine kinase whose expression is up-regulated in sev...
Protein tyrosine kinase 6 (PTK6) is a non-receptor tyrosine kinase expressed in epithelial cancers. ...
<div><p>Protein tyrosine kinase 6 (PTK6, or BRK) is aberrantly expressed in breast cancers, and emer...
Protein tyrosine kinase 6 (PTK6, or BRK) is aberrantly expressed in breast cancers, and emerging as ...
Background We previously showed that pancreatic stellate cells (PSC) secreted interleukin (IL)-6 and...
Background Protein tyrosine phosphatase kappa (PTPRK) is a phosphatase which is recognised as a tumo...
<div><p>Pancreatic cancer is a very aggressive disease with few therapeutic options. In this study, ...
Pancreatic cancer is a very aggressive disease with few therapeutic options. In this study, we inves...
Pancreatic cancer, one of the deadliest human malignancies, is almost invariably associated with the...
Protein Tyrosine Kinase 6 (PTK6) is a non-receptor type tyrosine kinase that may be involved in some...
<p><b><i>A</i>,</b> Overexpression of PTK6. Cells were transfected with pcDNA3.1-Mock (empty vector)...
<p><b><i>A</i>,</b> PTK6 gene silencing. Cells were transfected with PTK6-specific siRNA (siRNA-PTK6...
<p><b><i>A</i>,</b> Effect of PTK6 gene silencing on total ERK1/2 and activated (phosphorylated) ERK...
PTK6, also known as Brk, is highly expressed in over 80% of breast cancers. In the last decade sever...
The non-receptor tyrosine kinase, PTK6/BRK, is highly expressed in multiple tumor types, including p...
PTK6 (also known as Brk) is an intracellular tyrosine kinase whose expression is up-regulated in sev...
Protein tyrosine kinase 6 (PTK6) is a non-receptor tyrosine kinase expressed in epithelial cancers. ...
<div><p>Protein tyrosine kinase 6 (PTK6, or BRK) is aberrantly expressed in breast cancers, and emer...
Protein tyrosine kinase 6 (PTK6, or BRK) is aberrantly expressed in breast cancers, and emerging as ...
Background We previously showed that pancreatic stellate cells (PSC) secreted interleukin (IL)-6 and...
Background Protein tyrosine phosphatase kappa (PTPRK) is a phosphatase which is recognised as a tumo...
<div><p>Pancreatic cancer is a very aggressive disease with few therapeutic options. In this study, ...
Pancreatic cancer is a very aggressive disease with few therapeutic options. In this study, we inves...
Pancreatic cancer, one of the deadliest human malignancies, is almost invariably associated with the...