Add to ORKGThe innate immune system is the first line of host defense against infection and involves several different cell types. Here we investigated the role of the phosphatidylinositol 3 kinase (PI3K) signaling pathway in innate immune cells. By blocking this pathway with pharmacological inhibitors, we found that the production of proinflammatory cytokines was drastically suppressed in monocytes and macrophages. Further study revealed that the suppression was mainly related to the mammalian target of rapamycin (mTOR)/p70S6K signaling. In addition, we found that the PI3K pathway was involved in macrophage motility and neovascularization. Our data provide a rationale that inhibition of the PI3K signaling pathway could be an attractive approach for t...
The healthy immune system protects against infection and malignant transformation without causing si...
International audienceThe PI3K-AKT-mTOR signaling axis is a critical molecular pathway in humans, re...
Lipopolysaccharide (LPS) activates a broad range of signalling pathways including mainly NF-kappaB a...
The innate immune system is the first line of host defense against infection and involves several di...
<div><p>The innate immune system is the first line of host defense against infection and involves se...
The phosphoinositide 3-kinase/mammalian target of rapamycin/protein kinase B (PI3K/mTOR/Akt) signali...
Macrophages play critical, but opposite, roles in acute and chronic inflammation and cancer. In resp...
Macrophages play critical, but opposite, roles in acute and chronic inflammation and cancer. In resp...
Macrophages play critical, but opposite, roles in acute and chronic inflammation and cancer. In resp...
Bacterial flagellin triggers inflammatory responses. Phosphoinositide 3-kinase (PI3K) and mammalian ...
<div><p>Bacterial flagellin triggers inflammatory responses. Phosphoinositide 3-kinase (PI3K) and ma...
The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield Ptd...
Immunotherapy has led to a paradigm shift in the treatment of some malignancies, providing long-term...
SummaryThe innate inflammatory immune response must be tightly controlled to avoid damage to the hos...
AbstractPI3Ks regulate several key events in the inflammatory response to damage and infection. Ther...
The healthy immune system protects against infection and malignant transformation without causing si...
International audienceThe PI3K-AKT-mTOR signaling axis is a critical molecular pathway in humans, re...
Lipopolysaccharide (LPS) activates a broad range of signalling pathways including mainly NF-kappaB a...
The innate immune system is the first line of host defense against infection and involves several di...
<div><p>The innate immune system is the first line of host defense against infection and involves se...
The phosphoinositide 3-kinase/mammalian target of rapamycin/protein kinase B (PI3K/mTOR/Akt) signali...
Macrophages play critical, but opposite, roles in acute and chronic inflammation and cancer. In resp...
Macrophages play critical, but opposite, roles in acute and chronic inflammation and cancer. In resp...
Macrophages play critical, but opposite, roles in acute and chronic inflammation and cancer. In resp...
Bacterial flagellin triggers inflammatory responses. Phosphoinositide 3-kinase (PI3K) and mammalian ...
<div><p>Bacterial flagellin triggers inflammatory responses. Phosphoinositide 3-kinase (PI3K) and ma...
The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield Ptd...
Immunotherapy has led to a paradigm shift in the treatment of some malignancies, providing long-term...
SummaryThe innate inflammatory immune response must be tightly controlled to avoid damage to the hos...
AbstractPI3Ks regulate several key events in the inflammatory response to damage and infection. Ther...
The healthy immune system protects against infection and malignant transformation without causing si...
International audienceThe PI3K-AKT-mTOR signaling axis is a critical molecular pathway in humans, re...
Lipopolysaccharide (LPS) activates a broad range of signalling pathways including mainly NF-kappaB a...