Add to ORKGBackground: There is considerable debate as to the relative merits of using randomised controlled trial (RCT) data as opposed to observational data in systematic reviews of adverse effects. This meta-analysis of meta-analyses aimed to assess the level of agreement or disagreement in the estimates of harm derived from meta-analysis of RCTs as compared to meta-analysis of observational studies. Methods and Findings: Searches were carried out in ten databases in addition to reference checking, contacting experts, citation searches, and hand-searching key journals, conference proceedings, and Web sites. Studies were included where a pooled relative measure of an adverse effect (odds ratio or risk ratio) from RCTs could be directly compared, usi...
Background: Adverse consequences of medical interventions are a source of concern, but clinical tri...
Introduction Although interest in including non-randomised studies of interventions (NRSIs) in meta-...
Background: Adverse consequences of medical interventions are a source of concern, but clinical tri...
Background: There is considerable debate as to the relative merits of using randomised controlled tr...
Background: There is considerable debate as to the relative merits of using randomised controlled tr...
There is considerable debate as to the relative merits of using randomised c...
A diverse range of study designs (e.g. case-control or cohort) are used in the evaluation of adverse...
Background: A diverse range of study designs (e.g. case-control or cohort) are used in the evaluatio...
A diverse range of study designs (e.g. case-control or cohort) are used in the evaluation of adverse...
Some authors argue that systematic reviews and meta-analyses of intervention studies should include ...
<div><p>Background</p><p>A diverse range of study designs (e.g. case-control or cohort) are used in ...
To compare effect estimates of randomised clinical trials that use routinely collected data (RCD-RCT...
BACKGROUND: There have been ongoing efforts to understand when and how data from observational studi...
BACKGROUND: There have been ongoing efforts to understand when and how data from observational studi...
BACKGROUND: There have been ongoing efforts to understand when and how data from observational studi...
Background: Adverse consequences of medical interventions are a source of concern, but clinical tri...
Introduction Although interest in including non-randomised studies of interventions (NRSIs) in meta-...
Background: Adverse consequences of medical interventions are a source of concern, but clinical tri...
Background: There is considerable debate as to the relative merits of using randomised controlled tr...
Background: There is considerable debate as to the relative merits of using randomised controlled tr...
There is considerable debate as to the relative merits of using randomised c...
A diverse range of study designs (e.g. case-control or cohort) are used in the evaluation of adverse...
Background: A diverse range of study designs (e.g. case-control or cohort) are used in the evaluatio...
A diverse range of study designs (e.g. case-control or cohort) are used in the evaluation of adverse...
Some authors argue that systematic reviews and meta-analyses of intervention studies should include ...
<div><p>Background</p><p>A diverse range of study designs (e.g. case-control or cohort) are used in ...
To compare effect estimates of randomised clinical trials that use routinely collected data (RCD-RCT...
BACKGROUND: There have been ongoing efforts to understand when and how data from observational studi...
BACKGROUND: There have been ongoing efforts to understand when and how data from observational studi...
BACKGROUND: There have been ongoing efforts to understand when and how data from observational studi...
Background: Adverse consequences of medical interventions are a source of concern, but clinical tri...
Introduction Although interest in including non-randomised studies of interventions (NRSIs) in meta-...
Background: Adverse consequences of medical interventions are a source of concern, but clinical tri...