ease (CAD) are frequently coexisting disorders and three diseases has remained largely unknown.

Full list of author information is available at the end of the articlemajor components of metabolic syndrome that cause a substantial public health and economic burden world-wide. Susceptibility to such complex diseases is strongly influenced by multiple genetic factors combined with environmental factors, and all these diseases are further characterized by a chronic inflammatory process. The strong genetic basis has been successfully revealed for Actually, evidence has showed that some loci confer risk for more than one of the studied diseases, and most common diseases arise from interaction between multiple genetic variations. This point suggested the concept of common genetic underpinnings for common diseases [1]. For example, a Wellcome Trust Case Control Consortium study evaluated 3,000 shared controls and 2,000 cases for each of seven complex human diseases—bipolar disorder, CAD, Crohn’s disease, hypertension, rheumatoid arthritis, type 1 diabetes, and 2DM—and demonstrated common susceptibility regions for rheumatoid arthritis and type 1 diabetes [2]. The common genetic basis for 2DM an