Treatment Outcome for Gastric Mucosa-Associated Lymphoid Tissue Lymphoma according to Helicobacter pylori Infection Status: A Single- Center Experience

Background/Aims: Helicobacter pylori eradication therapy has been used as a first-line treatment for H. pylori-positive gastric mucosa-associated lymphoid tissue (MALT) lympho-ma. However, the management strategy for H. pylori-negative MALT lymphoma remains controversial. Therefore, the aim of this study was to examine the success rate of each treat-ment option for H. pylori-positive and H. pylori-negative gastric MALT lymphomas. Methods: In total, 57 patients with gastric MALT lymphoma diagnosed between December 2000 and June 2012 were enrolled in the study. The treat-ment responses were compared between H. pylori-positive and H. pylori-negative gastric MALT lymphomas. Results: Of the 57 patients, 43 (75%) had H. pylori infection. Forty-eight patients received H. pylori eradication as a first-line treat-ment, and complete remission was achieved in 31 of the 3