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Abstract: Aging can be defined as a process of progressive decline in the physiological capacity of an organism, mani-fested by accumulated alteration and destabilization at the whole system level. Systems biology approaches offer a prom-ising new perspective to examine the old problem of aging. We begin this review by introducing the concepts of systems biology, and then illustrate the application of systems biology approaches to aging research, from gene expression profil-ing to network analysis. We then introduce the network that can be constructed using known lifespan and aging regula-tors, and conclude with a look forward to the future of systems biology in aging research. In summary, systems biology is not only a young field that may help us understand aging at a higher level, but also an important platform that can link dif-ferent levels of knowledge on aging, moving us closer to a more comprehensive control of systematic decline during aging