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Implication for health policy/practice/research/medical education: Cyclosporine can be considered a valid option for treatment of severe psoriasis in the setting of chronic HCV infection. Background: Treatment of psoriasis in the setting of chronic hepatitis C virus (HCV) in-fection is difficult, because standard therapies like methotrexate are associated with in-creased hepatic toxicity. Due to the HCV suppressive effect. Cyclosporine may represent a valid systemic alternative for psoriatic-HCV patients. Objectives: In this study, we report the successful usage of intermittent cycles of cyclo-sporine in the setting of chronic HCV infection and we try to call the attention once again in a very effective and forgotten therapeutic option for severe chronic plaque psoriasis. Observation: We describe a 48 years- old patient who has a 20 year history of severe chronic plaque psoriasis and HCV infection (aminotransferase levels are three times nor-mal; HCV genotype 2a-2c and HCV-RNA titer of 2.050.000 UI-ml). Five courses (range of duration of three to six months) of oral cyclosporine (5 mg/kg/day) were followed dur-ing a 38 month period. The viral load and the transaminases ’ levels diminished during the 38 months of intermittent cyclosporine therapy to the lowest level measured at 36t