NANO EXPRESS Influence of nanoparticles d

ve e g he e p op ns cit [6,7]. the cell structures [12]. Prasek et al. Nanoscale Research Letters 2013, 8:251 http://www.nanoscalereslett.com/content/8/1/251ration due to the low pH in endosomes [1]. It was alsoCopenhagen, Groennegaardsvej 3, Frederiksberg 1870, Denmark Full list of author information is available at the end of the articleNanotechnology has introduced possibilities for using alternate forms of elements- nanoparticles. Nanoparticles have unique physiochemical features because of their small size (<100 nm), large surface-to-mass ratio, excep-tional quantum characteristics [8], and consequently unique biological properties. Smaller nanoparticles can It has been demonstrated that hadron cancer therapy can be amplified by simultaneous application of NP-Pt, resulting in the production of hydroxyl radicals causing lethal DNA damage by double-strand breaks [14]. Fur-thermore, DNA damage could also be induced by the attack of OH groups linked with NP-Pt on DNA phos-phate groups [2]. NP-Pt can also cause cell cycle arrest and induction of apoptosis through the release of Pt2+ ions from the nanoparticles as a result of H2O2 gene-* Correspondence