Add to ORKGGenetic diversity across different human populations can enhance understanding of the genetic basis of disease. We calculated the genetic risk of 102 diseases in 1,043 unrelated individuals across 51 populations of the Human Genome Diversity Panel. We found that genetic risk for type 2 diabetes and pancreatic cancer decreased as humans migrated toward East Asia. In addition, biliary liver cirrhosis, alopecia areata, bladder cancer, inflammatory bowel disease, membranous nephropathy, systemic lupus erythematosus, systemic sclerosis, ulcerative colitis, and vitiligo have undergone genetic risk differentiation. This analysis represents a large-scale attempt to characterize genetic risk differentiation in the context of migration. We anticipate...
The current thesis applied migration, twin, candidate gene, genome-wide association and genetic risk...
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 d...
The study of migrant populations has been employed in epidemiological studies to better characterize...
Genetic diversity across different human populations can enhance understanding of the genetic basis ...
Risk of disease is multifactorial and can be shaped by socio-economic, demographic, cultural, enviro...
Many disease-susceptible SNPs exhibit significant disparity in ancestral and derived allele frequenc...
varied widely across the loci studied (for example, 0.019 to 0.201 for type 2 diabetes, 0.022 to 0.5...
Many disease-susceptible SNPs exhibit significant disparity in ancestral and derived allele frequenc...
The successes of genome-wide association (GWA) studies have mainly come from studies performed in po...
<div><p>Many disease-susceptible SNPs exhibit significant disparity in ancestral and derived allele ...
Molecular and genetic approaches now provide powerful tools for investigating the origin of human po...
Identifying the causes of similarities and differences in genetic disease prevalence among humans is...
Wide genome analyses of vast population samples permitted by rapid technological progress (high-thro...
Abstract Complex disorders are caused by a combination of genetic, environmental and lifestyle facto...
Background: Searching for associations between genetic variants and complex diseases has been a very...
The current thesis applied migration, twin, candidate gene, genome-wide association and genetic risk...
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 d...
The study of migrant populations has been employed in epidemiological studies to better characterize...
Genetic diversity across different human populations can enhance understanding of the genetic basis ...
Risk of disease is multifactorial and can be shaped by socio-economic, demographic, cultural, enviro...
Many disease-susceptible SNPs exhibit significant disparity in ancestral and derived allele frequenc...
varied widely across the loci studied (for example, 0.019 to 0.201 for type 2 diabetes, 0.022 to 0.5...
Many disease-susceptible SNPs exhibit significant disparity in ancestral and derived allele frequenc...
The successes of genome-wide association (GWA) studies have mainly come from studies performed in po...
<div><p>Many disease-susceptible SNPs exhibit significant disparity in ancestral and derived allele ...
Molecular and genetic approaches now provide powerful tools for investigating the origin of human po...
Identifying the causes of similarities and differences in genetic disease prevalence among humans is...
Wide genome analyses of vast population samples permitted by rapid technological progress (high-thro...
Abstract Complex disorders are caused by a combination of genetic, environmental and lifestyle facto...
Background: Searching for associations between genetic variants and complex diseases has been a very...
The current thesis applied migration, twin, candidate gene, genome-wide association and genetic risk...
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 d...
The study of migrant populations has been employed in epidemiological studies to better characterize...