at the nucleus in cardiac myocytes by Timothy D. O’Connell Journal of Cardiovasular Pharmacology, 2015 65:2;89–90) Abstract: Although convention dictates that G protein-coupled receptors localize to and signal at the plasma membrane, accumulating evidence suggests that G protein-coupled receptors localize to and signal at intracellular membranes, most notably the nucleus. In fact, there is now significant evidence indicating that endogenous alpha-1 adrenergic receptors (a1-ARs) localize to and signal at the nuclei in adult cardiac myocytes. Cumulatively, the data suggest that a1-ARs localize to the inner nuclear membrane, activate intranuclear signaling, and regulate physiologic function in adult cardiac myocytes. Although a1-ARs signal thr...
The well‐known condition of heart failure is a clinical syndrome that results when the myocardium's ...
RationaleIt is unknown whether every ventricular myocyte expresses all 5 of the cardiac adrenergic r...
The ability of the heart to augment the perfusion of vitalorgans and skeletal muscles during stress ...
Background-—Recent studies indicate that a1-adrenergic receptors (a1-ARs) are cardioprotective by pr...
Adrenergic receptors (AR) are G-protein-coupled receptors (GPCRs) that have a crucial role in cardia...
The heart is richly innervated by sympathetic nerves, and both acute and chronic regulation of cardi...
Abstract: βarrestin (βarr)-1 and-2 (βarrs) (or Arrestin-2 and-3, respectively) are universal G prote...
Cardiac hypertrophy is a complex remodeling process of the heart induced by physiological or patholo...
Cardiac hypertrophy is a complex remodeling process of the heart induced by physiological or patholo...
G protein-coupled receptors (GPCRs) are cell surface receptors that for many years have been conside...
RationaleGq signaling in cardiac myocytes is classically considered toxic. Targeting Gq directly to ...
Adenosine is a purine nucleoside, which is produced primarily through the metabolism of adenosine tr...
University of Minnesota Ph.D. dissertation.March 2018. Major: Pharmacology. Advisor: Timothy O'Conn...
Alpha-1-adrenergic receptors are G-protein coupled receptors (GPCRs) activated by catecholamines. Th...
BackgroundTranslation of preclinical findings could benefit from a simple, reproducible, high throug...
The well‐known condition of heart failure is a clinical syndrome that results when the myocardium's ...
RationaleIt is unknown whether every ventricular myocyte expresses all 5 of the cardiac adrenergic r...
The ability of the heart to augment the perfusion of vitalorgans and skeletal muscles during stress ...
Background-—Recent studies indicate that a1-adrenergic receptors (a1-ARs) are cardioprotective by pr...
Adrenergic receptors (AR) are G-protein-coupled receptors (GPCRs) that have a crucial role in cardia...
The heart is richly innervated by sympathetic nerves, and both acute and chronic regulation of cardi...
Abstract: βarrestin (βarr)-1 and-2 (βarrs) (or Arrestin-2 and-3, respectively) are universal G prote...
Cardiac hypertrophy is a complex remodeling process of the heart induced by physiological or patholo...
Cardiac hypertrophy is a complex remodeling process of the heart induced by physiological or patholo...
G protein-coupled receptors (GPCRs) are cell surface receptors that for many years have been conside...
RationaleGq signaling in cardiac myocytes is classically considered toxic. Targeting Gq directly to ...
Adenosine is a purine nucleoside, which is produced primarily through the metabolism of adenosine tr...
University of Minnesota Ph.D. dissertation.March 2018. Major: Pharmacology. Advisor: Timothy O'Conn...
Alpha-1-adrenergic receptors are G-protein coupled receptors (GPCRs) activated by catecholamines. Th...
BackgroundTranslation of preclinical findings could benefit from a simple, reproducible, high throug...
The well‐known condition of heart failure is a clinical syndrome that results when the myocardium's ...
RationaleIt is unknown whether every ventricular myocyte expresses all 5 of the cardiac adrenergic r...
The ability of the heart to augment the perfusion of vitalorgans and skeletal muscles during stress ...