CORRESPONDENCE

Individuals with mutations in BRCA1 have a high risk of developing breast and ovarian cancer. Although BRCA1 is implicated in many cellular processes, its role in HR (Moynahan et al., 1999; Stark et al., 2004) is thought to be critical for tumor suppression and maintenance of genomic stability (Silver and Livingston, 2012). Tumor suppressor functions of BRCA1 are mediated by the BRCA1 carboxyl-terminal (BRCT) domain (Shakya et al., 2011), a motif that binds phos-phorylated serine motifs in three different DNA repair proteins: BACH1 (BRIP1), ABRAXAS (CCDC98), and CtIP (Rbbp8; Li and Greenberg, 2012). Among these complexes, BRCA1 asso-ciation with CtIP has been implicated in nu-cleolytic resection of DNA double strand breaks (DSBs; Sartori et al., 2007; Chen et al., 2008)