Kindlin-1 is an integrin tail binding protein that controls integrin activation. Mutations in the FERMT-1 gene lead to Kindler Syndrome in man, which is characterized by skin blistering, premature skin ageing and skin cancer of unknown etiology. Here we show that loss of Kindlin-1 in mouse keratinocytes recapitulates Kindler Syndrome, and in addition produces enlarged and hyperactive stem cell compartments, which lead to hyperthickened epidermis, ectopic hair follicle development and increased skin tumor susceptibility. Mechanistically, Kindlin-1 controls keratinocyte adhesion through β1-class integrins and proliferation and differentiation of cutaneous epithelial stem cells by promoting αvβ6 integrin-mediated TGFβ activation and by inhibit...
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Kindler syndrome is an autosomal recessive disorder characterized by skin atrophy and blistering. It...
Mutations of integrin-interacting protein Kindlin-1 cause Kindler syndrome and deregulation of Kindl...
Mutations of integrin-interacting protein Kindlin-1 cause Kindler Syndrome and deregulation of Kindl...
Kindlin-1 is an integrin tail binding protein that controls integrin activation. Mutations in the FE...
Loss-of-function mutations in the gene encoding the integrin co-activator kindlin-1 cause Kindler sy...
<div><p>Loss-of-function mutations in the gene encoding the integrin co-activator kindlin-1 cause Ki...
Kindler syndrome (KS) is an autosomal recessive blistering skin disease resulting from pathogenic mu...
Kindlin-1 is a scaffold protein linking the cytoskeleton to the extracellular matrix. Loss of functi...
Kindler syndrome (KS) is a rare disorder leading to keratinocyte fragility, poikiloderma and palmar ...
Kindler Syndrome (KS), characterized by transient skin blistering followed by abnormal pigmentation,...
Background Fermitin family member 1 (FERMT1, Kindlin-1) is an epithelial-specific regulator of integ...
Fermitin family member 1 (FERMT1, Kindlin-1) is an epithelial-specific regulator of integrin functio...
Kindler syndrome is caused by genetic defects in the focal contact-associated protein, fermitin fami...
Kindler syndrome (KS) is an autosomal recessive blistering skin disease resulting from pathogenic mu...
Loss of function of KIND1, a cytoskeletal protein involved in beta 1-integrin function, causes Kindl...
Kindler syndrome is an autosomal recessive disorder characterized by skin atrophy and blistering. It...
Mutations of integrin-interacting protein Kindlin-1 cause Kindler syndrome and deregulation of Kindl...
Mutations of integrin-interacting protein Kindlin-1 cause Kindler Syndrome and deregulation of Kindl...
Kindlin-1 is an integrin tail binding protein that controls integrin activation. Mutations in the FE...
Loss-of-function mutations in the gene encoding the integrin co-activator kindlin-1 cause Kindler sy...
<div><p>Loss-of-function mutations in the gene encoding the integrin co-activator kindlin-1 cause Ki...
Kindler syndrome (KS) is an autosomal recessive blistering skin disease resulting from pathogenic mu...
Kindlin-1 is a scaffold protein linking the cytoskeleton to the extracellular matrix. Loss of functi...
Kindler syndrome (KS) is a rare disorder leading to keratinocyte fragility, poikiloderma and palmar ...
Kindler Syndrome (KS), characterized by transient skin blistering followed by abnormal pigmentation,...
Background Fermitin family member 1 (FERMT1, Kindlin-1) is an epithelial-specific regulator of integ...
Fermitin family member 1 (FERMT1, Kindlin-1) is an epithelial-specific regulator of integrin functio...
Kindler syndrome is caused by genetic defects in the focal contact-associated protein, fermitin fami...
Kindler syndrome (KS) is an autosomal recessive blistering skin disease resulting from pathogenic mu...
Loss of function of KIND1, a cytoskeletal protein involved in beta 1-integrin function, causes Kindl...
Kindler syndrome is an autosomal recessive disorder characterized by skin atrophy and blistering. It...
Mutations of integrin-interacting protein Kindlin-1 cause Kindler syndrome and deregulation of Kindl...
Mutations of integrin-interacting protein Kindlin-1 cause Kindler Syndrome and deregulation of Kindl...
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