DOI 10.1007/s00439-014-1427-3 OrIGInal InvestIGatIOn Characterization of the DYX2 locus on chromosome 6p22 with reading disability, language impairment, and IQ

© the author(s) 2014. this article is published with open access at springerlink.com the DYX2 locus with rD, lI, and IQ. to accomplish this, we developed a marker panel densely covering the 1.4 Mb DYX2 locus and assessed association with reading, lan-guage, and IQ measures in subjects from the avon lon-gitudinal study of Parents and Children. We then repli-cated associations in three independent, disorder-selected cohorts. as expected, there were associations with known rD risk genes KIAA0319 and DCDC2. In addition, we implicated markers in or near other DYX2 genes, includ-ing TDP2, ACOT13, C6orf62, FAM65B, and CMAHP. However, the lD structure of the locus suggests that asso-ciations within TDP2, ACOT13, and C6orf62 are captur-ing a previously reported risk variant in KIAA0319. Our results further substantiate the candidacy of KIAA0319 an