ARTICLE Retinal proteome alterations in a mouse model of type

Aims/hypothesis Diabetic retinopathy is a major complication of type 2 diabetes and the leading cause of blindness in adults of working age. Neuronal defects are known to occur early in disease, but the source of this dysfunction is unknown. The aim of this study was to examine differences in the retinal membrane proteome among non-diabetic mice and mouse models of diabetes either with or without metformin treatment. Methods Alterations in the retinal membrane proteome of 10-week-old diabetic db/db mice, diabetic db/db mice orally treated with the anti-hyperglycaemic met-formin, and congenic wild-type littermates were exam-ined using label-free mass spectrometry. Pathway en-richment analysis was completed with Genomatix an