The aim of the present study was to test the biocompatibility and functionality of orthopaedic bone implants with immobilized oligonucleotides serving as anchor stands for rhBMP-2 and rhVEGF-A conjugated with complementary oligonucleotides in an osteoporotic rat model. Al2O3-blasted acid etched Ti6Al4V implants, carrying oligonucleotide anchor strands and hybridized with rhBMP-2 or rhVEGF-A through complementary 31-mer oligonucleotide stands were inserted into the proximal tibia of ovariectomized rats. At the time of surgery (15 weeks after ovariectomy) microCT analysis showed significantly lower bone mineral density compared to non-ovariectomized animals. Bone-implant contact (BIC) and pullout-force were not negatively affected by non-hybr...
This study hypothesized that modification of titanium implant surface, e.g. by the deposition of ino...
This study investigated bone regeneration in the femoral neck canal of osteoporotic rats using a nov...
<p>AAT: Al<sub>2</sub>O<sub>3</sub>-blasted acid etched titanium; ODN: anchor strands of oligonucleo...
The aim of the present study was to test the biocompatibility and functionality of orthopaedic bone ...
The aim of the present study was to test the hypothesis that immobilisation of bone morphogenic prot...
Aseptic loosening of implants is the major cause for revision surgery. By modulating the bone-implan...
Aseptic loosening of implants is the major cause for revision surgery. By modulating the bone-implan...
<p>Bone-to-implant contact rate was highest in the BMP group (median 60.7%) 12 weeks after surgery t...
Shortening of the healing time before loading risks impeding successful titanium implant anchorage i...
Osteoporosis often leads to fragility fractures of the hip resulting in impaired quality of life and...
Osteoporosis often leads to fragility fractures of the hip, resulting in impaired quality of life an...
The present study examined the impact of implant surface modifications on osseointegration in an ost...
Patients with osteoporosis and joint disabilities represent a constant growing and challenging popul...
Objectives:This study evaluated the influence of ovariectomy 8 weeks after implant placement on bone...
This study investigated bone regeneration in the femoral neck canal of osteoporotic rats using a nov...
This study hypothesized that modification of titanium implant surface, e.g. by the deposition of ino...
This study investigated bone regeneration in the femoral neck canal of osteoporotic rats using a nov...
<p>AAT: Al<sub>2</sub>O<sub>3</sub>-blasted acid etched titanium; ODN: anchor strands of oligonucleo...
The aim of the present study was to test the biocompatibility and functionality of orthopaedic bone ...
The aim of the present study was to test the hypothesis that immobilisation of bone morphogenic prot...
Aseptic loosening of implants is the major cause for revision surgery. By modulating the bone-implan...
Aseptic loosening of implants is the major cause for revision surgery. By modulating the bone-implan...
<p>Bone-to-implant contact rate was highest in the BMP group (median 60.7%) 12 weeks after surgery t...
Shortening of the healing time before loading risks impeding successful titanium implant anchorage i...
Osteoporosis often leads to fragility fractures of the hip resulting in impaired quality of life and...
Osteoporosis often leads to fragility fractures of the hip, resulting in impaired quality of life an...
The present study examined the impact of implant surface modifications on osseointegration in an ost...
Patients with osteoporosis and joint disabilities represent a constant growing and challenging popul...
Objectives:This study evaluated the influence of ovariectomy 8 weeks after implant placement on bone...
This study investigated bone regeneration in the femoral neck canal of osteoporotic rats using a nov...
This study hypothesized that modification of titanium implant surface, e.g. by the deposition of ino...
This study investigated bone regeneration in the femoral neck canal of osteoporotic rats using a nov...
<p>AAT: Al<sub>2</sub>O<sub>3</sub>-blasted acid etched titanium; ODN: anchor strands of oligonucleo...