Early bilateral hippocampal lesions in transient global amnesia: Evidence against delayed ischemia?

A 65-year-old right-handed female was admitted to neurology after she suddenly began experiencing problems with her memory. Her past medical history was significant for osteoarthritis and a fractured clavicle, but there were no vascular risk factors, head trauma, migraine or epilepsy. She did not smoke, occasionally drank alcohol and denied illicit drug use. Her mother had passed away at 98 years of age without any sign of Alzheimer’s disease but one of her aunts was diagnosed with Alzheimer’s disease. She has four siblings, all were in good health, except for one brother with cardiac problems. On the day of the event, at 11:15 a.m. she began showing symptoms after a short bout of intense running for almost six minutes. She reported a vague sensation of confusion as to where she was and what she was doing, but nonetheless called her husband to pick her up. When he arrived, he noted her confusion in space and time, and she admitted to feeling dizzy. Upon arrival at their home, her confusion persisted. For example, she had forgotten about her sister’s birthday, and that they were renovating their kitchen. She repeatedly asked her husband “Why is there a present on the counter?”, or “Why is our kitchen such a mess?” After a few hours, she returned to normal level of functioning with no recollection of wha