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Full list of author information is available at the end of the articleical cases of P. vivax annually [2,3]. Although P. vivax is mainly endemic in Southeast Asia and Latin America [3], it has recently been observed in Ethiopia and Sudan [4-8]. Malaria is a important health problem in Sudan, and in 2002, an estimated 9 million disease episodes and 44,000 deaths from the disease occurred [9]. The spread of multidrug-resistant Plasmodium falciparum malaria in Sudan [10,11] has led to adoption of artemisinin-based priate drug is one of the main components of the World Health Organization’s strategy to reduce malaria related mortality [12]. Episodes of P. vivax infection should prompt urgent treatment with effective anti-malarial medication [13]. While most malaria endemic countries have adopted ACT to reduce the risk of multidrug re-sistant strains of P. falciparum occurring [10], chloro