Cancer Chemother Pharmacol (2011) 68:1243–1253 DOI 10.1007/s00280-011-1613-0ORIGINAL ARTICLE

Pharmacological factors affecting accumulation of gemcitabine's active metabolite, gemcitabine triphosphate

Rizzuto, Ivana
Ghazaly, Essam
Peters, Godefridus J

June 2017

Gemcitabine is an anticancer agent acting against several solid tumors. It requires nucleoside trans...

Characterizing Pancreatic Xenograft Tumor Response to Gemcitabine Treatment with Imaging Mass Spectrometry

Shedlock, Cameron

May 2022

Gemcitabine (Gem) is a first-line chemotherapeutic drug for treating pancreatic ductal adenocarcinom...

Measurement of the Anti-Cancer Agent Gemcitabine in Human Plasma by High-Performance Liquid Chromatography

Keith, Bruce
Xu, Yan
Grem, Jean L.

February 2003

A reversed-phase HPLC assay has been developed to determine the concentration of the anti-metabolite...

A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: comparison with (19)F NMR spectroscopy.

Bapiro, Tashinga E
Richards, Fran
Goldgraben, Mae
Olive, Kenneth P
Madhu, Basetti
Frese, Kristopher K
Cook, Natalie
Jacobetz, Michael A
Smith, Donna-Michelle
Tuveson, David
Griffiths, John
Jodrell, Duncan

November 2011

PURPOSE: To develop a sensitive analytical method to quantify gemcitabine (2',2'-difluorodeoxycytidi...

International Journal of Pharmaceutical ChemistryISSN: 2249-734X (Online) Journal DOI:10.7439/ijpcCODEN:IJPCI4 (American Chemical Society) Research Article RP-HPLC method for estimation of Gemcitabine HCl 1gm injection in parenteral dosage form

A Santosh
Kumar Sreevatsav
K. Shyam Sunder
Jayapal Maleraju

September 2016

Gemcitabine1 (2’-2’difluorodeoxycytidine) is a cytotoxic agent with wide spectrum of Anti tumor acti...

19F NMR in vivo spectroscopy reflects the effectiveness of perfusion-enhancing vascular modifiers for improving gemcitabine chemotherapy

Cron, Greg O.
Beghein, Nelson
Ansiaux, Réginald
Martinive, Philippe
Feron, Olivier
Gallez, Bernard

January 2008

Nuclear magnetic resonance spectroscopy of fluorine-19 ((19)F NMR) has proven useful for evaluating ...

19F NMR In Vivo Spectroscopy Reflects the Effectiveness of Perfusion-Enhancing Vascular Modifiers for Improving

Gemcitabine Chemotherapy
Olivier Feron
Bernard Gallez

February 2015

Nuclear magnetic resonance spectroscopy of fluorine-19 (19F NMR) has proven useful for evaluating ki...

Development and validation of LC-MS/MS methods for the quantification of the novel anticancer agent guadecitabine and its active metabolite β‑decitabine in human plasma, whole blood and urine

Roosendaal, Jeroen
Wang, Kai
Rosing, Hilde
Lucas, Luc
Gebretensae, Abadi
Oganesian, Aram
Schellens, Jan H M
Beijnen, Jos H
Lin, Zhongping John

March 2019

Guadecitabine (SGI-110), a dinucleotide of β‑decitabine and deoxyguanosine, is currently being evalu...

Development and validation of LC-MS/MS methods for the quantification of the novel anticancer agent guadecitabine and its active metabolite β‑decitabine in human plasma, whole blood and urine

Roosendaal, Jeroen
Wang, Kai
Rosing, Hilde
Lucas, Luc
Gebretensae, Abadi
Oganesian, Aram
Schellens, Jan H M
Beijnen, Jos H
Lin, Zhongping John
Afd Pharmacoepi & Clinical Pharmacology
Pharmacoepidemiology and Clinical Pharmacology

March 2019

Guadecitabine (SGI-110), a dinucleotide of β‑decitabine and deoxyguanosine, is currently being evalu...

Development and validation of LC-MS/MS methods for the quantification of the novel anticancer agent guadecitabine and its active metabolite β‑decitabine in human plasma, whole blood and urine

Roosendaal, Jeroen
Wang, Kai
Rosing, Hilde
Lucas, Luc
Gebretensae, Abadi
Oganesian, Aram
Schellens, Jan H M
Beijnen, Jos H
Lin, Zhongping John

March 2019

Guadecitabine (SGI-110), a dinucleotide of β‑decitabine and deoxyguanosine, is currently being evalu...

Development and validation of LC-MS/MS methods for the quantification of the novel anticancer agent guadecitabine and its active metabolite β‑decitabine in human plasma, whole blood and urine

Roosendaal, Jeroen
Wang, Kai
Rosing, Hilde
Lucas, Luc
Gebretensae, Abadi
Oganesian, Aram
Schellens, Jan H M
Beijnen, Jos H
Lin, Zhongping John

March 2019

Guadecitabine (SGI-110), a dinucleotide of β‑decitabine and deoxyguanosine, is currently being evalu...

Development and validation of LC-MS/MS methods for the quantification of the novel anticancer agent guadecitabine and its active metabolite β‑decitabine in human plasma, whole blood and urine

Roosendaal, Jeroen
Wang, Kai
Rosing, Hilde
Lucas, Luc
Gebretensae, Abadi
Oganesian, Aram
Schellens, Jan H M
Beijnen, Jos H
Lin, Zhongping John

March 2019

Guadecitabine (SGI-110), a dinucleotide of β‑decitabine and deoxyguanosine, is currently being evalu...

Method to visualize the intratumor distribution and impact of gemcitabine in pancreatic ductal adenocarcinoma by multimodal imaging

Strittmatter, Nicole
Richards, Frances M.
Race, Alan M.
Ling, Stephanie
Sutton, Daniel
Nilsson, Anna
Wallez, Yann
Barnes, Jennifer
Maglennon, Gareth
Gopinathan, Aarthi
Brais, Rebecca
Wong, Edmond
Serra, Maria Paola
Atkinson, James
Smith, Aaron
Wilson, Joanne
Hamm, Gregory
Johnson, Timothy I.
Dunlop, Charles R.
Kaistha, Brajesh P.
Bunch, Josephine
Sansom, Owen J.
Takats, Zoltan
Andrén, Per E.
Lau, Alan
Barry, Simon T.
Goodwin, Richard J.A.
Jodrell, Duncan I.

January 2022

Gemcitabine (dFdC) is a common treatment for pancreatic cancer; however, it is thought that treatmen...

Quantitative 19F MR spectroscopy at 3 T to detect heterogeneous capecitabine metabolism in human liver.

Klomp, D.W.J.
Laarhoven, H.W.M. van
Scheenen, T.W.J.
Kamm, Y.J.L.
Heerschap, A.

January 2007

Contains fulltext : 52890.pdf (publisher's version ) (Closed access)Chemotherapy i...

(19) F NMR in vivo spectroscopy reflects the effectiveness of perfusion - enhancing vascular modifiers for improving gemcitabine chemotheraypy

Cron, Greg O.
Ansiaux,
MARTINIVE, Philippe
Feron, O
Gallez, B

January 2008

Laboratory of Biomedical Magnetic Resonance and Laboratory of Medicinal Chemistry and Radiopharmacy,...

Pharmacological factors affecting accumulation of gemcitabine's active metabolite, gemcitabine triphosphate

Rizzuto, Ivana
Ghazaly, Essam
Peters, Godefridus J

June 2017

Gemcitabine is an anticancer agent acting against several solid tumors. It requires nucleoside trans...

Characterizing Pancreatic Xenograft Tumor Response to Gemcitabine Treatment with Imaging Mass Spectrometry

Shedlock, Cameron

May 2022

Gemcitabine (Gem) is a first-line chemotherapeutic drug for treating pancreatic ductal adenocarcinom...

Measurement of the Anti-Cancer Agent Gemcitabine in Human Plasma by High-Performance Liquid Chromatography

Keith, Bruce
Xu, Yan
Grem, Jean L.

February 2003

A reversed-phase HPLC assay has been developed to determine the concentration of the anti-metabolite...

A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: comparison with (19)F NMR spectroscopy.

Bapiro, Tashinga E
Richards, Fran
Goldgraben, Mae
Olive, Kenneth P
Madhu, Basetti
Frese, Kristopher K
Cook, Natalie
Jacobetz, Michael A
Smith, Donna-Michelle
Tuveson, David
Griffiths, John
Jodrell, Duncan

November 2011

PURPOSE: To develop a sensitive analytical method to quantify gemcitabine (2',2'-difluorodeoxycytidi...

International Journal of Pharmaceutical ChemistryISSN: 2249-734X (Online) Journal DOI:10.7439/ijpcCODEN:IJPCI4 (American Chemical Society) Research Article RP-HPLC method for estimation of Gemcitabine HCl 1gm injection in parenteral dosage form

A Santosh
Kumar Sreevatsav
K. Shyam Sunder
Jayapal Maleraju

September 2016

Gemcitabine1 (2’-2’difluorodeoxycytidine) is a cytotoxic agent with wide spectrum of Anti tumor acti...

19F NMR in vivo spectroscopy reflects the effectiveness of perfusion-enhancing vascular modifiers for improving gemcitabine chemotherapy

Cron, Greg O.
Beghein, Nelson
Ansiaux, Réginald
Martinive, Philippe
Feron, Olivier
Gallez, Bernard

January 2008

Nuclear magnetic resonance spectroscopy of fluorine-19 ((19)F NMR) has proven useful for evaluating ...

19F NMR In Vivo Spectroscopy Reflects the Effectiveness of Perfusion-Enhancing Vascular Modifiers for Improving

Gemcitabine Chemotherapy
Olivier Feron
Bernard Gallez

February 2015

Nuclear magnetic resonance spectroscopy of fluorine-19 (19F NMR) has proven useful for evaluating ki...

Development and validation of LC-MS/MS methods for the quantification of the novel anticancer agent guadecitabine and its active metabolite β‑decitabine in human plasma, whole blood and urine

Roosendaal, Jeroen
Wang, Kai
Rosing, Hilde
Lucas, Luc
Gebretensae, Abadi
Oganesian, Aram
Schellens, Jan H M
Beijnen, Jos H
Lin, Zhongping John

March 2019

Guadecitabine (SGI-110), a dinucleotide of β‑decitabine and deoxyguanosine, is currently being evalu...

Development and validation of LC-MS/MS methods for the quantification of the novel anticancer agent guadecitabine and its active metabolite β‑decitabine in human plasma, whole blood and urine

Roosendaal, Jeroen
Wang, Kai
Rosing, Hilde
Lucas, Luc
Gebretensae, Abadi
Oganesian, Aram
Schellens, Jan H M
Beijnen, Jos H
Lin, Zhongping John
Afd Pharmacoepi & Clinical Pharmacology
Pharmacoepidemiology and Clinical Pharmacology

March 2019

Guadecitabine (SGI-110), a dinucleotide of β‑decitabine and deoxyguanosine, is currently being evalu...

Development and validation of LC-MS/MS methods for the quantification of the novel anticancer agent guadecitabine and its active metabolite β‑decitabine in human plasma, whole blood and urine

Roosendaal, Jeroen
Wang, Kai
Rosing, Hilde
Lucas, Luc
Gebretensae, Abadi
Oganesian, Aram
Schellens, Jan H M
Beijnen, Jos H
Lin, Zhongping John

March 2019

Guadecitabine (SGI-110), a dinucleotide of β‑decitabine and deoxyguanosine, is currently being evalu...

Development and validation of LC-MS/MS methods for the quantification of the novel anticancer agent guadecitabine and its active metabolite β‑decitabine in human plasma, whole blood and urine

Roosendaal, Jeroen
Wang, Kai
Rosing, Hilde
Lucas, Luc
Gebretensae, Abadi
Oganesian, Aram
Schellens, Jan H M
Beijnen, Jos H
Lin, Zhongping John

March 2019

Guadecitabine (SGI-110), a dinucleotide of β‑decitabine and deoxyguanosine, is currently being evalu...

Development and validation of LC-MS/MS methods for the quantification of the novel anticancer agent guadecitabine and its active metabolite β‑decitabine in human plasma, whole blood and urine

Roosendaal, Jeroen
Wang, Kai
Rosing, Hilde
Lucas, Luc
Gebretensae, Abadi
Oganesian, Aram
Schellens, Jan H M
Beijnen, Jos H
Lin, Zhongping John

March 2019

Guadecitabine (SGI-110), a dinucleotide of β‑decitabine and deoxyguanosine, is currently being evalu...

Method to visualize the intratumor distribution and impact of gemcitabine in pancreatic ductal adenocarcinoma by multimodal imaging

Strittmatter, Nicole
Richards, Frances M.
Race, Alan M.
Ling, Stephanie
Sutton, Daniel
Nilsson, Anna
Wallez, Yann
Barnes, Jennifer
Maglennon, Gareth
Gopinathan, Aarthi
Brais, Rebecca
Wong, Edmond
Serra, Maria Paola
Atkinson, James
Smith, Aaron
Wilson, Joanne
Hamm, Gregory
Johnson, Timothy I.
Dunlop, Charles R.
Kaistha, Brajesh P.
Bunch, Josephine
Sansom, Owen J.
Takats, Zoltan
Andrén, Per E.
Lau, Alan
Barry, Simon T.
Goodwin, Richard J.A.
Jodrell, Duncan I.

January 2022

Gemcitabine (dFdC) is a common treatment for pancreatic cancer; however, it is thought that treatmen...

Quantitative 19F MR spectroscopy at 3 T to detect heterogeneous capecitabine metabolism in human liver.

Klomp, D.W.J.
Laarhoven, H.W.M. van
Scheenen, T.W.J.
Kamm, Y.J.L.
Heerschap, A.

January 2007

Contains fulltext : 52890.pdf (publisher's version ) (Closed access)Chemotherapy i...

(19) F NMR in vivo spectroscopy reflects the effectiveness of perfusion - enhancing vascular modifiers for improving gemcitabine chemotheraypy

Cron, Greg O.
Ansiaux,
MARTINIVE, Philippe
Feron, O
Gallez, B

January 2008

Laboratory of Biomedical Magnetic Resonance and Laboratory of Medicinal Chemistry and Radiopharmacy,...

Pharmacological factors affecting accumulation of gemcitabine's active metabolite, gemcitabine triphosphate

Rizzuto, Ivana
Ghazaly, Essam
Peters, Godefridus J

June 2017

Gemcitabine is an anticancer agent acting against several solid tumors. It requires nucleoside trans...

Characterizing Pancreatic Xenograft Tumor Response to Gemcitabine Treatment with Imaging Mass Spectrometry

Shedlock, Cameron

May 2022

Gemcitabine (Gem) is a first-line chemotherapeutic drug for treating pancreatic ductal adenocarcinom...

Measurement of the Anti-Cancer Agent Gemcitabine in Human Plasma by High-Performance Liquid Chromatography

Keith, Bruce
Xu, Yan
Grem, Jean L.

February 2003

A reversed-phase HPLC assay has been developed to determine the concentration of the anti-metabolite...

Cancer Chemother Pharmacol (2011) 68:1243–1253 DOI 10.1007/s00280-011-1613-0ORIGINAL ARTICLE

Abstract

Extracted data

Cancer Chemother Pharmacol (2011) 68:1243–1253 DOI 10.1007/s00280-011-1613-0ORIGINAL ARTICLE

Abstract

Extracted data

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