The Prevalence of Primary Angle Closure Glaucoma in Adult Asians: A Systematic Review and Meta-Analysis

Background: Primary angle closure glaucoma (PACG) is higher in Asians than Europeans and Africans, with over 80 % of PACG worldwide in Asia. Previous estimates of PACG were based largely on early studies, mostly using inappropriate case definitions. Therefore, we did a systematic review and meta-analysis to estimate the prevalence of PACG in adult Asian populations and to quantify its association with age, gender, and region. Methods: All primary reports of population-based studies that reported the prevalence of PACG in adult Asian populations were identified. PACG case definition was compatible with the ISGEO definition. Twenty-nine population-based studies were included. The overall pooled prevalence estimates were calculated using a random effect model, and ethnicity-, age-and gender-specific pooled prevalence estimates were also calculated. Results: The overall pooled prevalence of PACG in those of adult Asians was 0.75 % (95 % CI, 0.58, 0.96). Ethnicity-specifi