Background: The ability of human bone marrow mesenchymal stem cells (BM-MSCs) to migrate and localize specifically to injured tissues is central in developing therapeutic strategies for tissue repair and regeneration. Fibroblast activation protein (FAP) is a cell surface serine protease expressed at sites of tissue remodeling during embryonic development. It is also expressed in BM-MSCs, but not in normal tissues or cells. The function of FAP in BM-MSCs is not known. Principal Findings: We found that depletion of FAP proteins significantly inhibited the migration of BM-MSCs in a transwell chemotaxis assay. Such impaired migration ability of BM-MSCs could be rescued by re-expressing FAP in these cells. We then demonstrated that depletion of ...
Background: Fibroblast Activation Protein alpha (FAP-alpha) or seprase is an integral membrane serin...
Fibroblast activation protein (FAP) or seprase, which belongs to the group type II integral serine p...
Background: Giant cell arteritis (GCA) can present with serious acute complications such as blindnes...
BACKGROUND: The ability of human bone marrow mesenchymal stem cells (BM-MSCs) to migrate and localiz...
[[abstract]]BACKGROUND: The ability of human bone marrow mesenchymal stem cells (BM-MSCs) to migrate...
[[abstract]]BACKGROUND: The ability of human bone marrow mesenchymal stem cells (BM-MSCs) to migrate...
The ability of human bone marrow mesenchymal stem cells (BM-MSCs) to migrate and localize specifical...
The ability of human bone marrow mesenchymal stem cells (BM-MSCs) to migrate and localize specifical...
Mesenchymal stromal cell (MSC) therapies are being successfully developed for immune-mediated inflam...
Mesenchymal stromal cell (MSC) therapies are being successfully developed for immune-mediated inflam...
Background: Fibroblast activation protein-alpha (FAP alpha) is a type-II integral membrane serine pr...
BACKGROUND AIMS: The transmigratory capacity of bone marrow (BM) mesenchymal stromal cells (MSC) thr...
Fibroblast activation protein-alpha (FAP) identifies stromal cells of mesenchymal origin in human ca...
Background Fibroblast Activation Protein alpha (FAP-α) or seprase is an integral membrane serine pe...
Summary: Since hundreds of clinical trials are investigating the use of multipotent stromal cells (M...
Background: Fibroblast Activation Protein alpha (FAP-alpha) or seprase is an integral membrane serin...
Fibroblast activation protein (FAP) or seprase, which belongs to the group type II integral serine p...
Background: Giant cell arteritis (GCA) can present with serious acute complications such as blindnes...
BACKGROUND: The ability of human bone marrow mesenchymal stem cells (BM-MSCs) to migrate and localiz...
[[abstract]]BACKGROUND: The ability of human bone marrow mesenchymal stem cells (BM-MSCs) to migrate...
[[abstract]]BACKGROUND: The ability of human bone marrow mesenchymal stem cells (BM-MSCs) to migrate...
The ability of human bone marrow mesenchymal stem cells (BM-MSCs) to migrate and localize specifical...
The ability of human bone marrow mesenchymal stem cells (BM-MSCs) to migrate and localize specifical...
Mesenchymal stromal cell (MSC) therapies are being successfully developed for immune-mediated inflam...
Mesenchymal stromal cell (MSC) therapies are being successfully developed for immune-mediated inflam...
Background: Fibroblast activation protein-alpha (FAP alpha) is a type-II integral membrane serine pr...
BACKGROUND AIMS: The transmigratory capacity of bone marrow (BM) mesenchymal stromal cells (MSC) thr...
Fibroblast activation protein-alpha (FAP) identifies stromal cells of mesenchymal origin in human ca...
Background Fibroblast Activation Protein alpha (FAP-α) or seprase is an integral membrane serine pe...
Summary: Since hundreds of clinical trials are investigating the use of multipotent stromal cells (M...
Background: Fibroblast Activation Protein alpha (FAP-alpha) or seprase is an integral membrane serin...
Fibroblast activation protein (FAP) or seprase, which belongs to the group type II integral serine p...
Background: Giant cell arteritis (GCA) can present with serious acute complications such as blindnes...