with N-Cadherin for Junctional Localization

The two major cadherins of endothelial cells are neural (N)-cadherin and vascular endothelial (VE)-cadherin. Despite similar level of protein expression only VE-cadherin is located at cell–cell contacts, whereas N-cadherin is distributed over the whole cell membrane. Cotransfection of VE-cadherin and N-cad-herin in CHO cells resulted in the same distribution as that observed in endothelial cells indicating that the be-havior of the two cadherins was not cell specific but re-lated to their structural characteristics. Similar amounts o