African infants with vertically acquired HIV infection progress rapidly, with only 50 % surviving beyond 2 years in the absence of treatment. Despite this high initial mortality, recent reports describe a substantial burden of older children living with untreated vertically acquired HIV infection in Southern Africa. The immunological and genetic factors associated with long-term survival following vertical infection are poorly understood. We performed medium-to-high resolution HLA typing on DNA samples obtained from a cohort of presumed vertically HIV-1-infected children and age-matched uninfected controls in Harare, Zimbabwe. Overall, 93 HLA class I alleles were detected in the study population with a significant enrichment of HLA-C*08:02 ...
Overall, the time to AIDS after HIV-2 infection is longer than with HIV-1, and many individuals infe...
BACKGROUND: Mother-child human leukocyte antigen (HLA) concordance and maternal HLA homozygosity may...
Sixteen children over the age of 5 years (Group 1) have been identified out of 537 children infected...
African infants with vertically acquired HIV infection progress rapidly, with only 50% surviving bey...
An understanding of the molecular basis of immune recognition in human disease is essential for the ...
Disease progression varies among HIV-1-infected individuals. The present study aimed to explore poss...
Human leucocyte antigen (HLA) class I molecules present endogenously processed antigens to T-cells a...
The link between HLA types and HIV disease progression has been well established with alleles and re...
A broad Gag-specific CD8(+) T-cell response is associated with effective control of adult human immu...
HLA class I polymorphism has a major influence on adult HIV disease progression. An important mechan...
Background. Mother-child human leukocyte antigen (HLA) concordance andmaternalHLAhomozygositymay inc...
BACKGROUND: During untreated, chronic HIV-1 infection, plasma viral load (VL) is a relatively stable...
Background: Human leukocyte antigens play an integral role in the cytotoxic T-cell pathway and serve...
Overall, the time to AIDS after HIV-2 infection is longer than with HIV-1, and many individuals infe...
Two human leukocyte antigen (HLA) variants, HLA-B*57 and -B*81, are consistently known as favorable ...
Overall, the time to AIDS after HIV-2 infection is longer than with HIV-1, and many individuals infe...
BACKGROUND: Mother-child human leukocyte antigen (HLA) concordance and maternal HLA homozygosity may...
Sixteen children over the age of 5 years (Group 1) have been identified out of 537 children infected...
African infants with vertically acquired HIV infection progress rapidly, with only 50% surviving bey...
An understanding of the molecular basis of immune recognition in human disease is essential for the ...
Disease progression varies among HIV-1-infected individuals. The present study aimed to explore poss...
Human leucocyte antigen (HLA) class I molecules present endogenously processed antigens to T-cells a...
The link between HLA types and HIV disease progression has been well established with alleles and re...
A broad Gag-specific CD8(+) T-cell response is associated with effective control of adult human immu...
HLA class I polymorphism has a major influence on adult HIV disease progression. An important mechan...
Background. Mother-child human leukocyte antigen (HLA) concordance andmaternalHLAhomozygositymay inc...
BACKGROUND: During untreated, chronic HIV-1 infection, plasma viral load (VL) is a relatively stable...
Background: Human leukocyte antigens play an integral role in the cytotoxic T-cell pathway and serve...
Overall, the time to AIDS after HIV-2 infection is longer than with HIV-1, and many individuals infe...
Two human leukocyte antigen (HLA) variants, HLA-B*57 and -B*81, are consistently known as favorable ...
Overall, the time to AIDS after HIV-2 infection is longer than with HIV-1, and many individuals infe...
BACKGROUND: Mother-child human leukocyte antigen (HLA) concordance and maternal HLA homozygosity may...
Sixteen children over the age of 5 years (Group 1) have been identified out of 537 children infected...