Comparison of the Effects of Telbivudine and Entecavir Treatment on Estimated Glomerular Filtration Rate in Patients with Chronic Hepatitis B

Background/Aims: The aim of this study was to evaluate the estimated glomerular filtration rate (eGFR) during telbivudine (LdT) versus entecavir (ETV) treatment in chronic hepatitis B (CHB) patients with underlying comorbidities such as dia-betes mellitus (DM), hypertension, and cirrhosis. Methods: From 2010 to 2012, 116 CHB patients treated with LdT and 578 treated with ETV were compared in this real-practice co-hort. The mean changes in eGFR (Modification of Diet in Re-nal Disease [MDRD] formula) from baseline to months 6, 12, and 18 were analyzed using a linear mixed model. Results: In LdT-treated patients, the mean eGFR increased by 7.6 % at month 18 compared with the eGFR at baseline (MDRD for-mula in mL/min/1.73 m2). However, in ETV-treated patients, the mean eGFR decreased by 4.1 % at month 18 compared with the eGFR at baseline. In the LdT-treated patients wit