RESEARCH ARTICLE Impact of Dedicated Brain PET on Intended Patient Management in Participants of the National Oncologic PET Registry

Purpose: This study seeks to assess the impact of dedicated brain positron emission tomography (PET) with 2-deoxy-2-[18F]fluoro-D-glucose on intended management of patients with primary and metastatic brain tumors. Procedures: We analyzed demographic characteristics and evaluated change in intended management after PET, using previously described metrics, for patients in the National Oncologic PET Registry (NOPR) undergoing dedicated brain PET. For cases of primary brain tumors, comparisons to the overall NOPR cohort were made. Patient Profile: Between December 2006 and April 2009, 509 dedicated brain PET scans were done on 479 patients—367 (72.1%) for suspected or proven primary brain tumors and 142 (27.9%) for brain metastases. Compared with the overall NOPR cohort, subjects in the dedicated brain cohort were younger (41.3 % less than 65 years vs. 10.5 % overall, pG0.0001) and more frequently had functional limitations from their cancers (78.6 % vs. 62.3 % overall; odds ratio (OR) 2.2, 95 % CI 1.8–2.8). Results: The pre-PET patient management plans in the primary brain tumor and metastasi