Add to ORKGThe estrogen receptor alpha (ER) is a ligand-activated transcription factor that possesses two activating domains designated AF-1 and AF-2 that mediate its transcriptional activity. The role of AF-2 is to recruit coregulator protein complexes capa-ble of modifying chromatin condensation status. In contrast, the mechanism responsible for the ligand-independent AF-1 activity and for its synergistic functional interaction with AF-2 is unclear. In this study, we have identified the protein Na+/H+ Ex-changer RegulatoryFactor 2 (NHERF2) as an ER-associated coactivator that interacts predominantly with the AF-1 domain of the nuclear receptor. Overex-pression of NHERF2 in breast cancer MCF7 cells pro
Triple negative breast cancer (TNBC) patients cannot be treated with endocrine therapy or targeted t...
There is a strong association between estrogen exposure and breast cancer risk. Estrogen can activat...
The estrogen receptor (ER), a member of the superfamily of ligand-dependent transcriptional activato...
The estrogen receptor alpha (ER) is a ligand-activated transcription factor that possesses two activ...
Breast cancer is the most common malignancy in women in the Western world, accounting for 18% of all...
The human estrogen receptor (ER) contains two major activation functions (AFs) responsible for its t...
The human estrogen receptor (ER) contains two major activation functions (AFs) responsible for its t...
Estrogen receptor (ER), one member of nuclear hormone receptor (NR) family, is an estrogen-dependent...
Estrogen receptor alpha (ERα), a ligand-dependent transcription factor, mediates the expression of i...
Aims: To determine the role of Na+/H+ exchanger regulatory factor (NHERF1) in breast cancerogene...
AbstractNa+/H+ exchanger regulatory factor 1 (NHERF1) is a scaffold protein known to interact with a...
Estrogen receptor alpha (ERα), a ligand-dependent transcription factor, mediates the expression of i...
Na+/H+ exchanger regulatory factor 1 (NHERF1) is a scaffold protein known to interact with a number ...
International audienceThe estrogen receptor alpha (ER alpha) is key in regulating normal breast deve...
Background: Na+/H+ exchanger regulatory factor 1 (NHERF1) has been reported to interact with many ca...
Triple negative breast cancer (TNBC) patients cannot be treated with endocrine therapy or targeted t...
There is a strong association between estrogen exposure and breast cancer risk. Estrogen can activat...
The estrogen receptor (ER), a member of the superfamily of ligand-dependent transcriptional activato...
The estrogen receptor alpha (ER) is a ligand-activated transcription factor that possesses two activ...
Breast cancer is the most common malignancy in women in the Western world, accounting for 18% of all...
The human estrogen receptor (ER) contains two major activation functions (AFs) responsible for its t...
The human estrogen receptor (ER) contains two major activation functions (AFs) responsible for its t...
Estrogen receptor (ER), one member of nuclear hormone receptor (NR) family, is an estrogen-dependent...
Estrogen receptor alpha (ERα), a ligand-dependent transcription factor, mediates the expression of i...
Aims: To determine the role of Na+/H+ exchanger regulatory factor (NHERF1) in breast cancerogene...
AbstractNa+/H+ exchanger regulatory factor 1 (NHERF1) is a scaffold protein known to interact with a...
Estrogen receptor alpha (ERα), a ligand-dependent transcription factor, mediates the expression of i...
Na+/H+ exchanger regulatory factor 1 (NHERF1) is a scaffold protein known to interact with a number ...
International audienceThe estrogen receptor alpha (ER alpha) is key in regulating normal breast deve...
Background: Na+/H+ exchanger regulatory factor 1 (NHERF1) has been reported to interact with many ca...
Triple negative breast cancer (TNBC) patients cannot be treated with endocrine therapy or targeted t...
There is a strong association between estrogen exposure and breast cancer risk. Estrogen can activat...
The estrogen receptor (ER), a member of the superfamily of ligand-dependent transcriptional activato...