Dietary patterns, insulin sensitivity and inflammation in older adults

Background/Objectives—Several studies have linked dietary patterns to insulin sensitivity and systemic inflammation, which affect risk of multiple chronic diseases. The purpose of this study was to investigate the dietary patterns of a cohort of older adults, and examine relationships of dietary patterns with markers of insulin sensitivity and systemic inflammation. Subjects/Methods—The Health, Aging and Body Composition (Health ABC) Study is a prospective cohort study of 3075 older adults. In Health ABC, multiple indicators of glucose metabolism and systemic inflammation were assessed. Food intake was estimated with a modified Block food frequency questionnaire (FFQ). In this study, dietary patterns of 1751 participants with complete data were derived by cluster analysis. Results—Six clusters were identified, including a ‘Healthy foods ’ cluster, characterized by higher intake of lowfat dairy products, fruit, whole grains, poultry, fish and vegetables. In the main analysis, the ‘Healthy foods ’ cluster had significantly lower fasting insulin and HOMA-IR than the ‘Breakfast cereal ’ and ‘High-fat dairy products ’ clusters, and lower fasting glucose than the ‘High-fat dairy products ’ cluster (P ≤ 0.05). No differences were found in 2-hour glucose