RESEARCH ARTICLE lterations in regional hom r t

Full list of author information is available at the end of the articleMigraine headache is a common neurological disorder which causes significant individual and societal burden due to pain and environmental sensitivities [1]. It was ranked the seventh highest among specific causes of dis-ability globally. Migraine has two subtypes, and two thirds of migraine patients suffer from MWoA which is typically characterized as a unilateral and pulsating headache, and rent headache manifests in attacks lasting 4–72 hours and affects patients 1–14 times each month in the episodic form. It is aggravated by routine physical activity, and is accompanied by vomiting, nausea, photophobia or phono-phobia. Migraine may result in substantial pain, a decrea-sed overall quality of life, and cause higher risks for ischemic stroke, unstable angina, and affective disorders than people without migraine [3-6]. Advanced neuroimaging approaches have been employed to investigate structural and functional brain changes in migraineurs, and proved that migraine was a central ner