722 | A. Pombo and D. A. Starr Molecular Biology of the Cell MBoC | ASCB ANNUAL MEETING HIGHLIGHT Nuclear cell biology

How does the nucleus move within the cell? How is the nucleus compartmentalized? How is nuclear size maintained? How is chromatin organized within the nucleus? These are a few of the questions related to nuclear cell biology addressed by our Minisymposium. Dan Starr led off with a description of how nuclei migrate in Caenorhabditis elegans. A KASH protein in the outer nuclear mem-brane recruits microtubule motors to the nucleus. Live imaging of nuclear migration and microtubules suggests that kinesin-1 provides the major force to move nuclei. To resolve large cellular roadblocks, dynein mediates backward movements or dramatic nuclear rolling events (Fridolfsson and Starr, 2010). G. W. Gant Luxton discussed mechanisms of nuclear migration in wounded cultured fibroblasts. Nesprin2G, SUN2, lamin, and actin cables associate in transmembrane actin-associated nuclear (TAN