Background Reduced white matter integrity, as indicated by lower fractional anisotropy (FA) and higher mean diffusivity (MD), has been related to poorer perceptual speed (PS) performance. As the ε4 allele has been associated with lower white matter integrity in old age, this represents a potential mechanism through which APOEmay affect PS. Objective To examine whether the association between APOE and PS is mediated by white matter microstructure in very old persons without dementia. Method Participants were selected from the population-based SNAC-K study. After excluding per-sons with dementia, preclinical dementia, and other neurological disorders, 652 persons (age range 78–90) were included in the study, of which 89 had data on diffusion ...
Objective: The disconnectivity hypothesis postulates that partial loss of connecting white matter fi...
The human brain\u27s structure can change with age and different health conditions. A genetic risk f...
Alzheimer’s disease · Dementia · Cerebrospinal fluid · White matter lesions · Follow-up studies Back...
<div><p>Background</p><p>Reduced white matter integrity, as indicated by lower fractional anisotropy...
The ε4 allelic variant of the Apolipoprotein E gene (APOE ε4) is the best-established genetic risk f...
<div><p>Increasing age is associated with deficits in a wide range of cognitive domains as well as w...
Background: The ε4 allele of the apolipoprotein E gene (APOE-ε4) is the strongest genetic factor for...
Alzheimer's disease (AD) is a neurodegenerative disorder that causes atrophy in gray and white matte...
BACKGROUND AND PURPOSE: The basis for decreased vulnerability to AD among apoE 2 carriers is unknown...
International audienceBACKGROUND: The pathogenesis of mild cognitive impairment (MCI) is multifactor...
Context: The role of macrostructural white matter changes, such as atrophy and white matter lesions,...
Background: The epsilon 4 allele of the apolipoprotein E gene (APOE-epsilon 4) is the stiongest gene...
AbstractIntroductionLittle is still known about the effects of risk factors for Alzheimer's disease ...
The Apolipoprotein E (APOE) ɛ4 allele is the best-established genetic risk factor for sporadic Alzhe...
Human white matter integrity has been related to information processing speed, but it is unknown whe...
Objective: The disconnectivity hypothesis postulates that partial loss of connecting white matter fi...
The human brain\u27s structure can change with age and different health conditions. A genetic risk f...
Alzheimer’s disease · Dementia · Cerebrospinal fluid · White matter lesions · Follow-up studies Back...
<div><p>Background</p><p>Reduced white matter integrity, as indicated by lower fractional anisotropy...
The ε4 allelic variant of the Apolipoprotein E gene (APOE ε4) is the best-established genetic risk f...
<div><p>Increasing age is associated with deficits in a wide range of cognitive domains as well as w...
Background: The ε4 allele of the apolipoprotein E gene (APOE-ε4) is the strongest genetic factor for...
Alzheimer's disease (AD) is a neurodegenerative disorder that causes atrophy in gray and white matte...
BACKGROUND AND PURPOSE: The basis for decreased vulnerability to AD among apoE 2 carriers is unknown...
International audienceBACKGROUND: The pathogenesis of mild cognitive impairment (MCI) is multifactor...
Context: The role of macrostructural white matter changes, such as atrophy and white matter lesions,...
Background: The epsilon 4 allele of the apolipoprotein E gene (APOE-epsilon 4) is the stiongest gene...
AbstractIntroductionLittle is still known about the effects of risk factors for Alzheimer's disease ...
The Apolipoprotein E (APOE) ɛ4 allele is the best-established genetic risk factor for sporadic Alzhe...
Human white matter integrity has been related to information processing speed, but it is unknown whe...
Objective: The disconnectivity hypothesis postulates that partial loss of connecting white matter fi...
The human brain\u27s structure can change with age and different health conditions. A genetic risk f...
Alzheimer’s disease · Dementia · Cerebrospinal fluid · White matter lesions · Follow-up studies Back...