Clin Endosc 2014;47:478-489 478 Copyright © 2014 Korean Society of Gastrointestinal Endoscopy Prevention Strategies for Gastric Cancer: A Global Perspective

Despite the substantial burden of gastric cancer worldwide, population strategies for primary prevention have not been introduced in any country. Recognizing the causal role of Helicobacter pylori infection, there is increasing interest in population-based programs to eradicate the infection to prevent gastric cancer. Nonetheless, the paucity of available evidence on feasibility and effectiveness has pre-vented implementation of this approach. There are very few secondary prevention programs based on screening with endoscopy or ra-diography, notably in the Republic of Korea and Japan, two of the countries with the highest incidence rates of gastric cancer. In Korea, where the organized screening program is in place, survival rate of gastric cancer is as high as 67%. More research is needed to quantify the specific contribution of the screening program to observed declines in mortality rates. Gastric cancer screening is unlikely to be fea-sible in many Low-Middle Income Countries where the gastric cancer burden is high. Prevention strategies are still under development and the optimal approach may differ depending on local conditions and societal values. The present review gives an overview of the eti-ology and burden of the disease, and possible prevention strategies for countries and regions confronted with a significant burden of disease