Prognosis based on primary breast carcinoma instead of pathological nodal status

Summary In breast cancer patients. prognostic information required to plan post-surgical therapy is obtained mainly through axillary dissection. This study was designed to establish a new prognostic score based solely on parameters of the primary tumour as an alternative to axillary surgery in assessing prognosis. Eight different prognostic factors, including menopausal status, tumour size. grading. lymphatic invasion. desmoplasia. necrosis. c-erbB-2 and laminin receptor expression. were evaluated retrospectively on a large series of primary breast carcinoma patients. From multivariate analysis, four independent parameters were selected and examined. alone and in combination, for their prognostic potential. These parameters were used to generate a prognostic score that was analysed retrospectively in 467 NO-Nla patients to determine its predictive value for survival. The score. which includes variables such as tumour size, grading. laminin receptor and c-erbB-2 overexpression. was established based on the number of negative prognostic factors: score I refers to cases in which all four parameters reflect a good prognosis, scores 2 and 3 refer to tumours in which, respectively, one or two of the four parameters reflect a poor prognosis. whereas score 4 refers to tumours with three or four poor prognosis factors. Analysis of the overall survival of the four score groups shows that patients with score I tumours (22 % of the total) had the best prognosis with a 15 year survival of 82%. patients with score 2 and 3 had an intermediate prognosis. whereas score 4 patients had the poorest prognosis with a 15 year survival o