Serum Levels of Receptors for Advanced Glycation End Products in Normal-WeightandObeseChildrenBorn Small and Large for Gestational Age

OBJECTIVEdTo assess potential alterations in soluble and endogenous secretory receptors for advanced glycation end products (sRAGE and esRAGE) in normal-weight (NW) and obese (Ob) children born small (SGA) and large (LGA) compared with appropriate for gestational age (AGA) subjects and to explore if birth weight (BW), insulin resistance (IR), and obesity represent independent risk factors. RESEARCHDESIGNANDMETHODSdWe categorized 130 prepubertal children into six groups according to BW and obesity and evaluated sRAGE, esRAGE, and homeostasis model assessment of IR. RESULTSdsRAGE and esRAGE were lower in Ob SGA and LGA children than Ob AGA subjects (all P, 0.05), and in NW SGA and LGA children than NW AGA subjects (all P, 0.05). Interestingly, BW and IR were significantly and independently related to RAGE. CONCLUSIONSdsRAGE and esRAGE are decreased in SGA and LGA children, and BW and IR seem to play an important role in the reduction of RAGE. Diabetes Care 35:1361–1363, 2012 Children born small and large forgestational age (SGA and LGA)are at increased risk of cardio-metabolic complications later in life (1–4). Interestingly, in recent years, the soluble and endogenous secretory re-ceptors for advanced glycation end products (sRAGE and esRAGE) have been proven to be involved in the path-ogenesis of cardiovascular diseases (5–8). Our aims were to evaluate sRAGE and esRAGE in normal-weight (NW) and obese (Ob) prepubertal SGA and LGA children compared with subjects born appropriate for gestational age (AGA), and to explore the potential association of these markers with birth weight (BW), insulin resistance (IR), and obesity