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auThOr’s VIew The clinical course of colorectal carci-noma (CRC) critically depends on cancer cell-intrinsic features, including specific mutations, microsatellite instability, and epigenetic alterations, as well as on the tumor microenvironment, as shaped by the interaction of malignant and non-transformed cells. Tumor infiltration by cellular components of the adaptive immune system has been shown to predict the survival of CRC patients more effi-ciently than the tumor-node-metastasis (TNM) staging.1 However, the role of the innate immune system in CRC progres