Add to ORKGThe peripheral airway innervation of the lower respiratory tract of mammals is not completely functionally characterized. Recently, we have shown in rats that precision-cut lung slices (PCLS) respond to electric field stimulation (EFS) and provide a useful model to study neural airway responses in distal airways. Since airway responses are known to exhibit considerable species differences, here we examined the neural responses of PCLS prepared from mice, rats, guinea pigs, sheep, marmosets and humans. Peripheral neurons were activated either by EFS or by capsaicin. Bronchoconstriction in response to identical EFS conditions varied between species in magnitude. Frequency response curves did reveal further species-dependent differences of ner...
<p>A. Frequency response curve: The frequency (F) was increased from 1 Hz to 200 Hz, while the other...
1. Nerve growth factor induces an airway hyperresponsiveness in vivo in guinea-pigs, as we have show...
Bronchoconstriction has been proposed to underlie airway remodelling. However, the mechanisms involv...
The peripheral airway innervation of the lower respiratory tract of mammals is not completely functi...
<p><b>A.</b> Capsaicin was added to precision-cut lung slices (PCLS) at a concentration of 10 µM, ei...
<p>The PCLS from either rats (n = 5) (<b>A</b>), sheep (n = 4) (<b>B</b>), marmosets (n = 5) (<b>C</...
Bronchoconstriction is a characteristic symptom of various chronic obstructive respiratory diseases ...
<p>Capsaicin was applied to PCLS from the indicated species at a concentration of 10 µM and airway c...
LUDWIG. Responsiveness of and interactions between airways and tissue in guinea pigs during induced ...
Sympathetic nerves innervate the airways of most species but their reflex regulation has been essent...
We have identified the tracheal and laryngeal afferent nerves regulating cough in anaesthetized guin...
Stimulation of afferent C-fibers axons with capsaicin causes a release of neuropeptides. These senso...
To investigate the hypothesis that altered Ca2+ signaling in airway smooth muscle cells (SMCs) is re...
The diameter of the airways, and as a result airway resistance, are controlled by the contractile to...
The muscarinic receptor subtype mediating contraction of the guinea pig lung strip preparation was i...
<p>A. Frequency response curve: The frequency (F) was increased from 1 Hz to 200 Hz, while the other...
1. Nerve growth factor induces an airway hyperresponsiveness in vivo in guinea-pigs, as we have show...
Bronchoconstriction has been proposed to underlie airway remodelling. However, the mechanisms involv...
The peripheral airway innervation of the lower respiratory tract of mammals is not completely functi...
<p><b>A.</b> Capsaicin was added to precision-cut lung slices (PCLS) at a concentration of 10 µM, ei...
<p>The PCLS from either rats (n = 5) (<b>A</b>), sheep (n = 4) (<b>B</b>), marmosets (n = 5) (<b>C</...
Bronchoconstriction is a characteristic symptom of various chronic obstructive respiratory diseases ...
<p>Capsaicin was applied to PCLS from the indicated species at a concentration of 10 µM and airway c...
LUDWIG. Responsiveness of and interactions between airways and tissue in guinea pigs during induced ...
Sympathetic nerves innervate the airways of most species but their reflex regulation has been essent...
We have identified the tracheal and laryngeal afferent nerves regulating cough in anaesthetized guin...
Stimulation of afferent C-fibers axons with capsaicin causes a release of neuropeptides. These senso...
To investigate the hypothesis that altered Ca2+ signaling in airway smooth muscle cells (SMCs) is re...
The diameter of the airways, and as a result airway resistance, are controlled by the contractile to...
The muscarinic receptor subtype mediating contraction of the guinea pig lung strip preparation was i...
<p>A. Frequency response curve: The frequency (F) was increased from 1 Hz to 200 Hz, while the other...
1. Nerve growth factor induces an airway hyperresponsiveness in vivo in guinea-pigs, as we have show...
Bronchoconstriction has been proposed to underlie airway remodelling. However, the mechanisms involv...