Runx family transcription factors are essential for embryonic development and have key roles in hematopoiesis. They bind DNA through the conserved Runt domain and can activate or re-press transcription by cooperating with other sequence-specific transcription factors, coactiva-tors, and corepressors (Durst and Hiebert, 2004; Taniuchi and Littman, 2004). Runx1 (AML1) and Runx3 (AML2) are intimately linked to T cell fate choice and function by regulating tar-get genes that specify CD4/CD8 development in the thymus and the postthymic differentiation of Th1, Th2, and Th17 cells. Runx1 and Runx3 sequentially interact with the Cd4 silencer to block CD4 expression in double-negative and CD8 single-positive thymocytes (Taniuchi et al., 2002). Runx3...
Runx1 transcription factor is highly expressed at a CD4/CD8-double-negative (DN) stage of thymocyte ...
SummaryTo understand how CD8 expression is regulated during the transition process from CD4+8+ (CD4 ...
Developmental hematopoiesis sees the generation of the first blood cells and definitive blood during...
Runx proteins are essential for hematopoiesis and play an important role in T cell development by re...
Over the past years, increasing numbers of distinct subsets have been discovered and identified for ...
Runx proteins are essential for hematopoiesis and play an important role in T cell development by re...
Runx proteins are essential for hematopoiesis and play an important role in T cell development by re...
The runt family transcription factors Runx1 and Runx3 are expressed in developing murine thymocytes....
The runt family transcription factors Runx1 and Runx3 are expressed in developing murine thymocytes....
The runt family transcription factors Runx1 and Runx3 are expressed in developing murine thymocytes....
Runx proteins (also known as Runt-domain transcription factors) have been studied for a long time as...
The Runx1 transcription factor cooperates with or antagonizes other transcription factors and plays ...
SummaryT lymphocytes differentiate in discrete stages within the thymus. Immature thymocytes lacking...
Runx1 regulates the expression of several important target genes and plays critical roles in the pro...
Runx1 regulates the expression of several important target genes and plays critical roles in the pro...
Runx1 transcription factor is highly expressed at a CD4/CD8-double-negative (DN) stage of thymocyte ...
SummaryTo understand how CD8 expression is regulated during the transition process from CD4+8+ (CD4 ...
Developmental hematopoiesis sees the generation of the first blood cells and definitive blood during...
Runx proteins are essential for hematopoiesis and play an important role in T cell development by re...
Over the past years, increasing numbers of distinct subsets have been discovered and identified for ...
Runx proteins are essential for hematopoiesis and play an important role in T cell development by re...
Runx proteins are essential for hematopoiesis and play an important role in T cell development by re...
The runt family transcription factors Runx1 and Runx3 are expressed in developing murine thymocytes....
The runt family transcription factors Runx1 and Runx3 are expressed in developing murine thymocytes....
The runt family transcription factors Runx1 and Runx3 are expressed in developing murine thymocytes....
Runx proteins (also known as Runt-domain transcription factors) have been studied for a long time as...
The Runx1 transcription factor cooperates with or antagonizes other transcription factors and plays ...
SummaryT lymphocytes differentiate in discrete stages within the thymus. Immature thymocytes lacking...
Runx1 regulates the expression of several important target genes and plays critical roles in the pro...
Runx1 regulates the expression of several important target genes and plays critical roles in the pro...
Runx1 transcription factor is highly expressed at a CD4/CD8-double-negative (DN) stage of thymocyte ...
SummaryTo understand how CD8 expression is regulated during the transition process from CD4+8+ (CD4 ...
Developmental hematopoiesis sees the generation of the first blood cells and definitive blood during...