Add to ORKGInflammatory bowel disease is a chronic gastrointestinal inflammatory disorder associated with changes in neuropeptide expression and function, including vasoactive intestinal pep-tide (VIP). VIP regulates intestinal vasomotor and secretomotor function and motility; how-ever, VIP’s role in development and maintenance of colonic epithelial barrier homeostasis is unclear. Using VIP deficient (VIPKO) mice, we investigated VIP’s role in epithelial barrier homeostasis, and susceptibility to colitis. Colonic crypt morphology and epithelial barrier ho-meostasis were assessed in wildtype (WT) and VIPKOmice, at baseline. Colitic responses were evaluated following dinitrobenzene sulfonic acid (DNBS) or dextran-sodium sulfate (DSS) exposure. Mice were...
Background The extent to which numerous strains of genetically engineered mice, including mice lacki...
Citrobacter rodentium infection is a model for infection with attaching and effacing pathogens, such...
BACKGROUND: Vasostatin-1 (VS-1), the N-terminal fragment of chromogranin A (CgA), decreases the perm...
Inflammatory bowel disease is a chronic gastrointestinal inflammatory disorder associated with chang...
VIP is highly expressed in the colon and regulates motility, vasodilatation, and sphincter relaxatio...
Dysregulated homeostasis of epithelial cells resulting in disruption of mucosal barrier func-tion is...
Keratins (K) are important for epithelial stress protection as evidenced by keratin mutations predis...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
Background The receptor for formylated peptides, formyl peptide receptor 1 (FPR1), potently activate...
The cells of the intestinal epithelium provide a selectively permeable barrier between the external ...
Background: The dsRNA-activated protein kinase (PKR) phosphorylates the a subunit of eukaryotic tran...
Inflammatory bowel disease (IBD) is associated with prolonged, excess secretions of Tumor Necrosis F...
BACKGROUND & AIMS:: Hypoxia inducible factor (HIF) prolyl hydroxylase inhibitors are protective in m...
Gastrointestinal infections with EHEC and EPEC are responsible for outbreaks of diarrheal diseases a...
Background: The early molecular changes preceding the onset of mucosal inflammation in colitis and t...
Background The extent to which numerous strains of genetically engineered mice, including mice lacki...
Citrobacter rodentium infection is a model for infection with attaching and effacing pathogens, such...
BACKGROUND: Vasostatin-1 (VS-1), the N-terminal fragment of chromogranin A (CgA), decreases the perm...
Inflammatory bowel disease is a chronic gastrointestinal inflammatory disorder associated with chang...
VIP is highly expressed in the colon and regulates motility, vasodilatation, and sphincter relaxatio...
Dysregulated homeostasis of epithelial cells resulting in disruption of mucosal barrier func-tion is...
Keratins (K) are important for epithelial stress protection as evidenced by keratin mutations predis...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
Background The receptor for formylated peptides, formyl peptide receptor 1 (FPR1), potently activate...
The cells of the intestinal epithelium provide a selectively permeable barrier between the external ...
Background: The dsRNA-activated protein kinase (PKR) phosphorylates the a subunit of eukaryotic tran...
Inflammatory bowel disease (IBD) is associated with prolonged, excess secretions of Tumor Necrosis F...
BACKGROUND & AIMS:: Hypoxia inducible factor (HIF) prolyl hydroxylase inhibitors are protective in m...
Gastrointestinal infections with EHEC and EPEC are responsible for outbreaks of diarrheal diseases a...
Background: The early molecular changes preceding the onset of mucosal inflammation in colitis and t...
Background The extent to which numerous strains of genetically engineered mice, including mice lacki...
Citrobacter rodentium infection is a model for infection with attaching and effacing pathogens, such...
BACKGROUND: Vasostatin-1 (VS-1), the N-terminal fragment of chromogranin A (CgA), decreases the perm...