CASE REPORT Identification of a new BR

rq ez who have increased cancer risk because of the presence tions are reported in the Breast Cancer Information Core Timoteo et al. Hereditary Cancer in Clinical Practice (2015) 13:2 DOI 10.1186/s13053-014-0022-xlate presentation, where the majority of cases are invasiveNatal, RN, Brazil Full list of author information is available at the end of the articleof mutations in cancer susceptibility genes. In the major-ity of cases however, specific mutations have not yet been identified or cancers have arisen sporadically in the context of various risk factors, including a positive fam-ily history [1]. BRCA1 and BRCA2 are genes with large coding sequences, consisting of 51 exons in total and a large number of mutations have been characterized world-wide. Together, germline mutations in these two genes are considered to constitute approximately 6–7 % of breast (BIC) database [2] and the majority of mutations de-scribed are frameshift mutations which result in a trun-cated protein. Male breast cancer (MBC) accounts for less than 1 % of all male cancers and 0.65 % of all breast tumors [3-5], and men tend to be diagnosed at an older age than women (mean age is about 67 years). It is an infrequent, poorly characterized disease which is epidemiologically and biologically different from female breast cancer (FBC), and it is still unknown whether current paradigms and treatment of female disease can be extrapolated to MBC [6]. Decreased awareness of the existence of such a disease among male patients and physicians leads to its * Correspondence