Review Article Hepatitis C Virus Infection: Looking for Interferon

Copyright © 2013 J. González-Moreno and A. Payeras-Cifre.This is an open access article distributed under theCreativeCommons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Recent developments of newdrugs ’ combinations are changing the treatment paradigm in hepatitis C virus infection.Due to the side effect profile of pegylated interferons, interferon-sparing regimens have become the main target in chronic hepatitis C treatment research. Recent proofs of concept studies have suggested that cure of chronic hepatitis C can be achieved without interferon. The purpose of this paper is to provide an overview of the clinical results recently reported for the treatment of hepatitis C virus infection with interferon-free regimens, focusing on the most promising new compounds and combinations. 1