ABSTRACT Mammalian insulin-degrading enzyme (IDE) cleaves insulin, among other pep-tidic substrates, but its function in insulin signaling is elusive. We use the Drosophila system to define the function of IDE in the regulation of growth and metabolism. We find that either loss or gain of function of Drosophila IDE (dIDE) can restrict growth in a cell-autonomous man-ner by affecting both cell size and cell number. dIDE can modulate Drosophila insulin-like peptide 2 levels, thereby restricting activation of the phosphatidylinositol-3-phosphate ki-nase pathway and promoting activation of Drosophila forkhead box, subgroup O transcrip-tion factor. Larvae reared in high sucrose exhibit delayed developmental timing due to insulin resistance. We f...
Secreted ligands of the insulin family promote cell growth and maintain sugar homeostasis. Insulin r...
Mammalian insulin and insulin-like growth factors (IGFs) signal through several receptors with diffe...
A phylogenetically conserved response to nutritional abundance is an increase in insulin signaling, ...
Mammalian insulin-degrading enzyme (IDE) cleaves insulin, among other peptidic substrates, but its f...
The precise mechanism by which insulin is degraded in mammalian cells is not presently known. Severa...
AbstractInsulin-degrading enzyme (IDE) is implicated in the pathogenesis of type 2 diabetes mellitus...
AbstractDrosophila melanogaster has become a prominent and convenient model for analysis of insulin ...
BACKGROUND: Size regulation is fundamental in developing multicellular organisms and occurs through ...
AbstractBackground: Size regulation is fundamental in developing multicellular organisms and occurs ...
Recent studies have indicated that the insulin-signaling pathway controls body and organ size in Dro...
International audienceIn multicellular organisms, insulin/IGF signaling (IIS) plays a central role i...
<div><p>Recent studies have indicated that the insulin-signaling pathway controls body and organ siz...
<div><p>In multicellular organisms, insulin/IGF signaling (IIS) plays a central role in matching ene...
Complexity in multi-cellular life arises from the ability of tissues to communicate with each other;...
Abstract Growth and maturation are coordinated processes in all animals. Integration of internal cue...
Secreted ligands of the insulin family promote cell growth and maintain sugar homeostasis. Insulin r...
Mammalian insulin and insulin-like growth factors (IGFs) signal through several receptors with diffe...
A phylogenetically conserved response to nutritional abundance is an increase in insulin signaling, ...
Mammalian insulin-degrading enzyme (IDE) cleaves insulin, among other peptidic substrates, but its f...
The precise mechanism by which insulin is degraded in mammalian cells is not presently known. Severa...
AbstractInsulin-degrading enzyme (IDE) is implicated in the pathogenesis of type 2 diabetes mellitus...
AbstractDrosophila melanogaster has become a prominent and convenient model for analysis of insulin ...
BACKGROUND: Size regulation is fundamental in developing multicellular organisms and occurs through ...
AbstractBackground: Size regulation is fundamental in developing multicellular organisms and occurs ...
Recent studies have indicated that the insulin-signaling pathway controls body and organ size in Dro...
International audienceIn multicellular organisms, insulin/IGF signaling (IIS) plays a central role i...
<div><p>Recent studies have indicated that the insulin-signaling pathway controls body and organ siz...
<div><p>In multicellular organisms, insulin/IGF signaling (IIS) plays a central role in matching ene...
Complexity in multi-cellular life arises from the ability of tissues to communicate with each other;...
Abstract Growth and maturation are coordinated processes in all animals. Integration of internal cue...
Secreted ligands of the insulin family promote cell growth and maintain sugar homeostasis. Insulin r...
Mammalian insulin and insulin-like growth factors (IGFs) signal through several receptors with diffe...
A phylogenetically conserved response to nutritional abundance is an increase in insulin signaling, ...