POSTER PRESENTATION Open Access Exploring the relationships between neuronal parameters and network activity

This study constitutes our next step toward a full investi-gation of how intrinsic membrane and synaptic para-meters affect the electrical activity of a half-center oscillator (HCO) model and how different parameter regimes influence stability and modulatability of the HCO model’s output. In our previous study [3], we constructed an efficient relational database table with the resulting characteristics of Hill et al.’s [2] HCO single-compartment conductance-based model. This model consists of two reciprocally inhibitory neurons and replicates the electrical activity of the oscillator interneurons of the leech heart-beat CPG under a variety of experimental conditions. We systematically [4] explored the parameter space of this HCO model by varying a set of eight selected para-meters (maximal conductances of intrinsic and synapti