Introduction: Interleukin (IL)-36a is a newly described member of the IL-1 cytokine family with a known inflammatory and pathogenic function in psoriasis. Recently, we could demonstrate that the receptor (IL-36R), its ligand IL-36a and its antagonist IL-36Ra are expressed in synovial tissue of arthritis patients. Furthermore, IL-36a induces MAP-kinase and NFkB signaling in human synovial fibroblasts with subsequent expression and secretion of pro-inflammatory cytokines. Methods: To understand the pathomechanism of IL-36 dependent inflammation, we investigated the biological impact o
Hintergrund: Interleukin (IL)-36α ist ein neues Mitglied der Interleukin-1 Familie, dessen pro-entz...
Interleukin (IL)–36α, IL-36β, and IL-36γ are innate mediators of acute epithelial inflammation. We s...
Generalized pustular psoriasis is a severe skin disease characterized by epidermal hyperplasia, neut...
Introduction: Interleukin (IL)-36a is a newly described member of the IL-1 cytokine family with a kn...
INTRODUCTION: Interleukin (IL)-36α is a newly described member of the IL-1 cytokine family with a kn...
Background: Interleukin (IL)-36α is a recently described member of the IL-1 cytokine family with pro...
INTRODUCTION: Interleukin (IL)-36 refers to three related IL-1 family cytokines, IL-36α, IL-36β, and...
Given the known involvement of IL-36 in psoriasis it might be surprising that the latest mouse model...
The interleukin (IL)-36 cytokines include 3 agonists, IL-36α, IL-36β, and IL-36γ that bind to a comm...
IL-36a, IL-36b, and IL-36g are members of the IL-1 family of cytokines that signal through a common ...
The interleukin (IL)-1 family of cytokines is composed of 11 members, including the most recently di...
International audienceInterleukin (IL)-36a, IL-36b and IL-36g are expressed highly in skin and are i...
Interleukin (IL)-36α, IL-36β and IL-36γ are expressed highly in skin and are involved in the pathoge...
Psoriasis is an immune-mediated inflammatory skin disease that involves mainly T helper (Th)17, Th1 ...
The interleukin (IL)-1 family of cytokines is composed of 11 members, including the most recently di...
Hintergrund: Interleukin (IL)-36α ist ein neues Mitglied der Interleukin-1 Familie, dessen pro-entz...
Interleukin (IL)–36α, IL-36β, and IL-36γ are innate mediators of acute epithelial inflammation. We s...
Generalized pustular psoriasis is a severe skin disease characterized by epidermal hyperplasia, neut...
Introduction: Interleukin (IL)-36a is a newly described member of the IL-1 cytokine family with a kn...
INTRODUCTION: Interleukin (IL)-36α is a newly described member of the IL-1 cytokine family with a kn...
Background: Interleukin (IL)-36α is a recently described member of the IL-1 cytokine family with pro...
INTRODUCTION: Interleukin (IL)-36 refers to three related IL-1 family cytokines, IL-36α, IL-36β, and...
Given the known involvement of IL-36 in psoriasis it might be surprising that the latest mouse model...
The interleukin (IL)-36 cytokines include 3 agonists, IL-36α, IL-36β, and IL-36γ that bind to a comm...
IL-36a, IL-36b, and IL-36g are members of the IL-1 family of cytokines that signal through a common ...
The interleukin (IL)-1 family of cytokines is composed of 11 members, including the most recently di...
International audienceInterleukin (IL)-36a, IL-36b and IL-36g are expressed highly in skin and are i...
Interleukin (IL)-36α, IL-36β and IL-36γ are expressed highly in skin and are involved in the pathoge...
Psoriasis is an immune-mediated inflammatory skin disease that involves mainly T helper (Th)17, Th1 ...
The interleukin (IL)-1 family of cytokines is composed of 11 members, including the most recently di...
Hintergrund: Interleukin (IL)-36α ist ein neues Mitglied der Interleukin-1 Familie, dessen pro-entz...
Interleukin (IL)–36α, IL-36β, and IL-36γ are innate mediators of acute epithelial inflammation. We s...
Generalized pustular psoriasis is a severe skin disease characterized by epidermal hyperplasia, neut...